unc-5 unc-5 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: unc-5provided by FlyBase
Official Full Name: unc-5provided by FlyBase
Primary source: FLYBASE:FBgn0034013
Locus tag: Dmel_CG8166
See related: AllianceGenome:FB:FBgn0034013
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AAF7419; CG8166; CG8168; CT20824; Dmel\CG8166; dUnc5; Dunc5; Unc-5; UNC-5; unc5; Unc5; UNC5; Unc5d; UNC5D
Summary: Predicted to enable netrin receptor activity involved in chemorepulsion. Involved in neurogenesis; positive regulation of cell migration; and salivary gland boundary specification. Predicted to be located in membrane. Is expressed in several structures, including PNS glial cell; dorsal vessel primordium; embryonic/larval dorsal vessel; larval internal muscle motor neurons; and nerve. Orthologous to several human genes including UNC5A (unc-5 netrin receptor A); UNC5B (unc-5 netrin receptor B); and UNC5C (unc-5 netrin receptor C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (15340472..15368300)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (11227977..11255805)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables netrin receptor activity	IEA Inferred from Electronic Annotation more info
enables netrin receptor activity involved in chemorepulsion	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in netrin-activated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in salivary gland boundary specification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

Names: CG8166-PA; CG8166-PB; UNC5 protein; Unc-5; Uncoordinated5; unc-5-PA; unc-5-PB; unc-5-like; uncoordinated 5

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