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    CG10804 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31317, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10804provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029663
    Locus tag
    Dmel_CG10804
    See related
    AllianceGenome:FB:FBgn0029663
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG10804
    Summary
    Predicted to enable neurotransmitter:sodium symporter activity. Predicted to be involved in amino acid transport; neurotransmitter transport; and sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in anterior-posterior subdivision of organism; embryonic head sensory system; ganglia; and larval nervous system. Human ortholog(s) of this gene implicated in Hartnup disease and autosomal recessive intellectual developmental disorder 48. Orthologous to several human genes including SLC6A15 (solute carrier family 6 member 15); SLC6A17 (solute carrier family 6 member 17); and SLC6A18 (solute carrier family 6 member 18). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10804 in Genome Data Viewer
    Location:
    3D4-3D4; 1-3 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (3476463..3482322, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (3370496..3376355, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44999 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Branched-Chain Amino Acid Accumulation Fuels the Senescence-Associated Secretory Phenotype. Liang Y, et al. Adv Sci (Weinh), 2024 Jan. PMID 37964763, Free PMC Article
    2. Organization of Circadian Behavior Relies on Glycinergic Transmission. Frenkel L, et al. Cell Rep, 2017 Apr 4. PMID 28380364
    3. The Role of miRNAs in Drosophila melanogaster Male Courtship Behavior. Iftikhar H, et al. Genetics, 2019 Mar. PMID 30683757, Free PMC Article
    4. Comparative sequence analysis and tissue localization of members of the SLC6 family of transporters in adult Drosophila melanogaster. Thimgan MS, et al. J Exp Biol, 2006 Sep. PMID 16916974
    5. The invertebrate B(0) system transporter, D. melanogaster NAT1, has unique d-amino acid affinity and mediates gut and brain functions. Miller MM, et al. Insect Biochem Mol Biol, 2008 Oct. PMID 18718864, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables neurotransmitter transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables neurotransmitter:sodium symporter activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amino acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neurotransmitter transport ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in neurotransmitter transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10804-PA
    CG10804-PB
    CG10804-PC
    CG10804-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      3476463..3482322 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297910.1 → NP_001284839.1  uncharacterized protein Dmel_CG10804, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284839.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W4S0
      Conserved Domains (1) summary
      cd10332
      Location:56 → 597
      SLC6sbd-B0AT-like; System B(0) neutral amino acid transporter AT1, 2 and 3, and related proteins; solute-binding domain

    2. NM_130705.2 → NP_570061.1  uncharacterized protein Dmel_CG10804, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_570061.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W4S0
      Related
      FBpp0070567
      Conserved Domains (1) summary
      cd10332
      Location:56 → 597
      SLC6sbd-B0AT-like; System B(0) neutral amino acid transporter AT1, 2 and 3, and related proteins; solute-binding domain

    3. NM_166975.2 → NP_726868.1  uncharacterized protein Dmel_CG10804, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726868.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IRU1
      Related
      FBpp0070566
      Conserved Domains (1) summary
      cd10332
      Location:56 → 617
      SLC6sbd-B0AT-like; System B(0) neutral amino acid transporter AT1, 2 and 3, and related proteins; solute-binding domain

    4. NM_001144678.2 → NP_001138150.1  uncharacterized protein Dmel_CG10804, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138150.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z122
      Conserved Domains (1) summary
      cd10332
      Location:120 → 661
      SLC6sbd-B0AT-like; System B(0) neutral amino acid transporter AT1, 2 and 3, and related proteins; solute-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z122 B7Z122
    Q8IRU1 Q8IRU1
    Q9W4S0 Q9W4S0

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