Strica Ser/Thr-rich caspase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Stricaprovided by FlyBase
Official Full Name: Ser/Thr-rich caspaseprovided by FlyBase
Primary source: FLYBASE:FBgn0033051
Locus tag: Dmel_CG7863
See related: AllianceGenome:FB:FBgn0033051
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7863; Dmel\CG7863; dream; Dream; DREAM; Dream/Strica; strica; STRICA; Strica/Dream; STRICA/DREAM
Summary: Predicted to enable cysteine-type endopeptidase activity involved in execution phase of apoptosis. Involved in nurse cell apoptotic process; positive regulation of compound eye retinal cell programmed cell death; and salivary gland histolysis. Located in cytoplasm. Is expressed in several structures, including female germline cell; gut section; and salivary gland. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 42A8-42A8; 2-55 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (6020311..6023144, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (1907816..1910649, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that L(3)mbt chromosomal targeting requires proteins of a site-specific DNA binding complex Myb-MuvB (MMB core component Mip130)/DREAM.
Title: Chromatin reader L(3)mbt requires the Myb-MuvB/DREAM transcriptional regulatory complex for chromosomal recruitment.
The dREAM/Myb-MuvB complex and Grim are key regulators of the programmed death of neural precursor cells at the Drosophila posterior wing margin
Title: The dREAM/Myb-MuvB complex and Grim are key regulators of the programmed death of neural precursor cells at the Drosophila posterior wing margin.
Drosophila corazonin-producing interneuron programmed cell death utilizes dronc, strica, dcp-1, and ice
Title: Drosophila caspases involved in developmentally regulated programmed cell death of peptidergic neurons during early metamorphosis.
P-element excision was used to generate mutants of the initiator caspase strica. While null mutants of strica or another initiator caspase, dronc, display no ovary phenotype, strica exhibits redundancy with dronc, during both mid- and late oogenesis.
Title: The Drosophila caspases Strica and Dronc function redundantly in programmed cell death during oogenesis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c6020488-6020439 mobile_element_type = transposon:INE-1{}5803

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in compound eye retinal cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nurse cell apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in programmed cell death	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in salivary gland histolysis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Ser/Thr-rich caspase

Names: CG7863-PA; CG7863-PB; Ser/Thr-RIch-CAspase; Strica-PA; Strica-PB; dream; strica

NP_001260718.1

EC 3.4.22.-

NP_610193.1

EC 3.4.22.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

6020311..6023144 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273789.1 → NP_001260718.1 Ser/Thr-rich caspase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260718.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KHK9

Conserved Domains (1) summary

cl00042
Location:311 → 523

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
NM_136349.3 → NP_610193.1 Ser/Thr-rich caspase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_610193.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KHK9

Related

FBpp0085364

Conserved Domains (1) summary

cl00042
Location:311 → 523

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...