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    Doa Darkener of apricot [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43415, updated on 9-Dec-2024

    Summary

    Official Symbol
    Doaprovided by FlyBase
    Official Full Name
    Darkener of apricotprovided by FlyBase
    Primary source
    FLYBASE:FBgn0265998
    Locus tag
    Dmel_CG42320
    See related
    AllianceGenome:FB:FBgn0265998
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    0844/02; CG1658; CG31049; CG33204; CG33553; CG42320; Dmel\CG42320; doa; DOA; DOA/CLK2; l(3)01705; l(3)S084402; l(3)s2784; Msu
    Old locus tag
    Dmel_CG33204; Dmel_CG33553
    Summary
    Enables protein serine/threonine kinase activity. Involved in several processes, including negative regulation of male germ cell proliferation; positive regulation of Toll signaling pathway; and positive regulation of antimicrobial peptide production. Located in endoplasmic reticulum and nucleus. Is expressed in several structures, including Bolwig nerve; anterior-posterior subdivision of organism; ganglia; germ layer; and imaginal disc. Orthologous to several human genes including CLK2 (CDC like kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Doa in Genome Data Viewer
    Location:
    98F1-98F2; 3-97 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (28888073..28922772)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24713795..24748494)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Neprilysin-like 20 Neighboring gene Neprilysin-like 21 Neighboring gene Dpr-interacting protein gamma Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45669

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    NOT involved_in MAPK cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in blastoderm segmentation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in compound eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in compound eye photoreceptor development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in compound eye photoreceptor development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of male germ cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of Toll signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of antimicrobial peptide production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
    involved_in regulation of organelle transport along microtubule IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sex differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in sex differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in somatic sex determination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IC
    Inferred by Curator
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    darkener of apricot
    Names
    CG42320-PAB
    CG42320-PJ
    CG42320-PK
    CG42320-PL
    CG42320-PM
    CG42320-PN
    CG42320-PP
    CG42320-PR
    CG42320-PS
    CG42320-PT
    CG42320-PU
    CG42320-PV
    CG42320-PX
    CG42320-PY
    CG42320-PZ
    Doa-PAB
    Doa-PJ
    Doa-PK
    Doa-PL
    Doa-PM
    Doa-PN
    Doa-PP
    Doa-PR
    Doa-PS
    Doa-PT
    Doa-PU
    Doa-PV
    Doa-PX
    Doa-PY
    Doa-PZ
    lethal (3) S084402
    lethal (3) s2784
    mosaic suppressor
    NP_001014678.1
    NP_001014679.1
    NP_001014680.1
    NP_001014681.2
    NP_001014682.1
    NP_001036763.2
    NP_001036764.2
    NP_001036765.1
    NP_001138120.1
    NP_001138121.1
    NP_001138122.1
    NP_001247353.1
    NP_001247354.1
    NP_001368951.1
    NP_788758.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      28888073..28922772
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001014680.4NP_001014680.1  darkener of apricot, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014680.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V3J9
      Conserved Domains (2) summary
      smart00220
      Location:233547
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14134
      Location:220547
      PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases
    2. NM_001144648.3NP_001138120.1  darkener of apricot, isoform T [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138120.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V3J9
      Conserved Domains (2) summary
      smart00220
      Location:233547
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14134
      Location:220547
      PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases
    3. NM_001043300.3NP_001036765.1  darkener of apricot, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036765.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V3J9
      Conserved Domains (2) summary
      smart00220
      Location:233547
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14134
      Location:220547
      PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases
    4. NM_001144649.2NP_001138121.1  darkener of apricot, isoform U [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138121.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V3J9
      Conserved Domains (2) summary
      smart00220
      Location:233547
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14134
      Location:220547
      PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases
    5. NM_001043299.3NP_001036764.2  darkener of apricot, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036764.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KI03
      Conserved Domains (2) summary
      smart00220
      Location:233547
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14134
      Location:220547
      PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases
    6. NM_001382085.1NP_001368951.1  darkener of apricot, isoform AB [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JRF7
      Conserved Domains (1) summary
      cd14134
      Location:239566
      PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases
    7. NM_001014682.3NP_001014682.1  darkener of apricot, isoform S [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014682.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0R6
      Conserved Domains (2) summary
      smart00220
      Location:164478
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14134
      Location:151478
      PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases
    8. NM_001144650.1NP_001138122.1  darkener of apricot, isoform V [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138122.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0R6
      Conserved Domains (2) summary
      smart00220
      Location:164478
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14134
      Location:151478
      PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases
    9. NM_001014678.3NP_001014678.1  darkener of apricot, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014678.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29R32, Q8IML9
      Conserved Domains (2) summary
      smart00220
      Location:636950
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14134
      Location:623950
      PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases
    10. NM_001260424.1NP_001247353.1  darkener of apricot, isoform X [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247353.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6R9
      Conserved Domains (2) summary
      smart00220
      Location:536856
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14134
      Location:523856
      PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases
    11. NM_001014681.4NP_001014681.2  darkener of apricot, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014681.2

      Status: REVIEWED

      Conserved Domains (2) summary
      smart00220
      Location:16922012
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14134
      Location:16792012
      PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases
    12. NM_001043298.2NP_001036763.2  darkener of apricot, isoform Y [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036763.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0C4DHG9
      Conserved Domains (2) summary
      smart00220
      Location:11821502
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14134
      Location:11691502
      PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases
    13. NM_001014679.2NP_001014679.1  darkener of apricot, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014679.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P49762, Q86B73, Q8IMM0, Q8T041, Q95RC9, Q9VAR8
      Conserved Domains (4) summary
      smart00220
      Location:479799
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14134
      Location:466799
      PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases
      pfam08226
      Location:183256
      DUF1720; Domain of unknown function (DUF1720)
      pfam15424
      Location:188260
      ODAM; Odontogenic ameloblast-associated family
    14. NM_176581.4NP_788758.3  darkener of apricot, isoform R [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788758.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86B72
      Conserved Domains (2) summary
      smart00220
      Location:8761196
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14134
      Location:8631196
      PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases
    15. NM_001260425.1NP_001247354.1  darkener of apricot, isoform Z [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247354.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7Z3
      Conserved Domains (2) summary
      smart00220
      Location:622942
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14134
      Location:609942
      PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases