hpo hippo [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: hpoprovided by FlyBase
Official Full Name: hippoprovided by FlyBase
Primary source: FLYBASE:FBgn0261456
Locus tag: Dmel_CG11228
See related: AllianceGenome:FB:FBgn0261456
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11228; Dmel\CG11228; dMST; hipo; Hippo; Hpo; HPO; Hpo/Wts; MST; Mst1/2; MST2
Summary: Enables protein serine/threonine kinase activity. Involved in several processes, including eye morphogenesis; negative regulation of neurogenesis; and regulation of apoptotic process. Located in apicomedial cortex; cytosol; and membrane. Colocalizes with cell-cell junction. Is expressed in imaginal disc and organism. Used to study cancer; carcinoma; neurodegenerative disease; and obesity. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to several human genes including STK3 (serine/threonine kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 56D13-56D13; 2-89 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (19493996..19496856, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (15381501..15384361, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hippo effector, Yorkie, is a tumor suppressor in select Drosophila squamous epithelia.
Title: Hippo effector, Yorkie, is a tumor suppressor in select Drosophila squamous epithelia.
The Mst1/2-BNIP3 axis is required for mitophagy induction and neuronal viability under mitochondrial stress.
Title: The Mst1/2-BNIP3 axis is required for mitophagy induction and neuronal viability under mitochondrial stress.
Combined inactivation of RB and Hippo converts differentiating Drosophila photoreceptors into eye progenitor cells through derepression of homothorax.
Title: Combined inactivation of RB and Hippo converts differentiating Drosophila photoreceptors into eye progenitor cells through derepression of homothorax.
Negative feedback couples Hippo pathway activation with Kibra degradation independent of Yorkie-mediated transcription.
Title: Negative feedback couples Hippo pathway activation with Kibra degradation independent of Yorkie-mediated transcription.
Suppression of Patronin deficiency by altered Hippo signaling in Drosophila organ development.
Title: Suppression of Patronin deficiency by altered Hippo signaling in Drosophila organ development.
SHANK2 is a frequently amplified oncogene with evolutionarily conserved roles in regulating Hippo signaling.
Title: SHANK2 is a frequently amplified oncogene with evolutionarily conserved roles in regulating Hippo signaling.
Silence of yki by miR-7 regulates the Hippo pathway.
Title: Silence of yki by miR-7 regulates the Hippo pathway.
Hippo signaling promotes Ets21c-dependent apical cell extrusion in the Drosophila wing disc.
Title: Hippo signaling promotes Ets21c-dependent apical cell extrusion in the Drosophila wing disc.
Mask, a component of the Hippo pathway, is required for Drosophila eye morphogenesis.
Title: Mask, a component of the Hippo pathway, is required for Drosophila eye morphogenesis.
Spectrin couples cell shape, cortical tension, and Hippo signaling in retinal epithelial morphogenesis.
Title: Spectrin couples cell shape, cortical tension, and Hippo signaling in retinal epithelial morphogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (134)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in R8 cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hippo signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in hippo signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hippo signaling	TAS Traceable Author Statement more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IGI Inferred from Genetic Interaction more info	PubMed
involved_in morphogenesis of an epithelial sheet	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in organ growth	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein destabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein tetramerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein processing	IDA Inferred from Direct Assay more info	PubMed
involved_in response to ionizing radiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinal cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in stem cell proliferation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in apicomedial cortex	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: hippo

Names: CG11228-PA; CG11228-PB; HIPPO; MST; hippo kinase; hpo-PA; hpo-PB

NP_001261092.1

EC 2.7.11.1

NP_611427.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

19493996..19496856 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001274163.1 → NP_001261092.1 hippo, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261092.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8T0S6, Q9V8W4

UniProtKB/TrEMBL

A0A0B4KFW0

Conserved Domains (3) summary

cd06612
Location:38 → 293

STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2

smart00220
Location:42 → 293

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam11629
Location:608 → 655

Mst1_SARAH; C terminal SARAH domain of Mst1
NM_137583.5 → NP_611427.1 hippo, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_611427.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8T0S6, Q9V8W4

UniProtKB/TrEMBL

A0A0B4KFW0

Related

FBpp0085688

Conserved Domains (3) summary

cd06612
Location:38 → 293

STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2

smart00220
Location:42 → 293

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam11629
Location:608 → 655

Mst1_SARAH; C terminal SARAH domain of Mst1