trio trio [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: trioprovided by FlyBase
Official Full Name: trioprovided by FlyBase
Primary source: FLYBASE:FBgn0024277
Locus tag: Dmel_CG18214
See related: AllianceGenome:FB:FBgn0024277
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0368/10; 0959/14; 1372/03; 1386/06; BEST:LD36950; CG18214; CG9208; Dmel\CG18214; dTrio; DTrio; l(3)036810; l(3)6D104; l(3)S036810; l(3)S095914; l(3)S137203; l(3)S138606; l(3)S[1372/3]; l(3)S[1386/06]; l(3)trio; M89; Trio; TRIO; UNC-73/Trio
Summary: Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including nervous system development; positive regulation of Rho protein signal transduction; and positive regulation of synaptic assembly at neuromuscular junction. Located in growth cone. Is extrinsic component of cytoplasmic side of plasma membrane. Is expressed in several structures, including epidermis; mushroom body; synaptic neuropil domain; synaptic neuropil subdomain; and ventral nerve cord. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder; autosomal dominant intellectual developmental disorder 44; cerebral atherosclerosis; cerebral infarction; and coronary artery disease. Orthologous to human KALRN (kalirin RhoGEF kinase) and TRIO (trio Rho guanine nucleotide exchange factor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 61E1-61E2; 3-0.5 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (995982..1034875, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (995982..1034875, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results have shown that trio expression in the class IV dendritic arborization sensory neurons rescues the blocked larval-pupal transition phenotype in seq-enhanced trio mutant larvae.
Title: The function of Drosophila larval class IV dendritic arborization sensory neurons in the larval-pupal transition is separable from their function in mechanical nociception responses.
Notch directly regulates the cell morphogenesis genes Reck, talin and trio in adult muscle progenitor
Title: Notch directly regulates the cell morphogenesis genes Reck, talin and trio in adult muscle progenitors.
allele of sequoia dominantly enhances a trio mutant phenotype to influence Drosophila larval behavior
Title: An allele of sequoia dominantly enhances a trio mutant phenotype to influence Drosophila larval behavior.
the primary function of Syd-1 in R7 photoreceptors may be to promote Trio activity.
Title: Loss of syd-1 from R7 neurons disrupts two distinct phases of presynaptic development.
Trio shapes the complexity of dendritic arbors and does so in a way that mimics the effects of its target, Rac.
Title: Control of dendritic morphogenesis by Trio in Drosophila melanogaster.
Data show that one of the two GEF domains of Trio, the Rac-specific GEF1, is essential for Trio-dependent motor axon guidance and for the genetic suppression of Notch function in motor axon patterning.
Title: Noncanonical Notch function in motor axon guidance is mediated by Rac GTPase and the GEF1 domain of Trio.
Transgenic expression of Trio in motor neurons can partially restore neuromuscular junction defects in larvae mutant for bone morphogenic protein.
Title: Retrograde BMP signaling controls synaptic growth at the NMJ by regulating trio expression in motor neurons.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm2291 (e-PCR)
- UniSTS:24507

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in actin cytoskeleton organization	IEP Inferred from Expression Pattern more info	PubMed
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon target recognition	IGI Inferred from Genetic Interaction more info	PubMed
involved_in central nervous system development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived leg morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peripheral nervous system development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in peripheral nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Rho protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of axonogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extrinsic component of cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extrinsic component of membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: trio

Names: CG18214-PA; CG18214-PB; CG18214-PC; CG18214-PD; CG18214-PE; CG18214-PF; CG18214-PG; trio-PA; trio-PB; trio-PC; trio-PD; trio-PE; trio-PF; trio-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

995982..1034875 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_143703.3 → NP_651960.2 trio, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_651960.2

Status: REVIEWED

UniProtKB/TrEMBL

Q7KVD1, Q9W0L0, Q9W0L1

Related

FBpp0072539

Conserved Domains (8) summary

smart00150
Location:1125 → 1226

SPEC; Spectrin repeats

cd11852
Location:1643 → 1707

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:13 → 152

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00176
Location:782 → 997

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1462 → 1584

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2130 → 2260

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

pfam00169
Location:1495 → 1580

PH; PH domain

pfam00621
Location:1287 → 1456

RhoGEF; RhoGEF domain
NM_167847.2 → NP_728560.1 trio, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728560.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KVD1, Q9W0L0, Q9W0L1

Related

FBpp0072540

Conserved Domains (8) summary

smart00150
Location:1125 → 1226

SPEC; Spectrin repeats

cd11852
Location:1643 → 1707

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:13 → 152

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00176
Location:782 → 997

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1462 → 1584

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2130 → 2260

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

pfam00169
Location:1495 → 1580

PH; PH domain

pfam00621
Location:1287 → 1456

RhoGEF; RhoGEF domain
NM_167848.2 → NP_728561.1 trio, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728561.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IRI5

Related

FBpp0072541

Conserved Domains (3) summary

cd11852
Location:184 → 248

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd13241
Location:671 → 801

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

pfam00621
Location:486 → 663

RhoGEF; RhoGEF domain
NM_167849.2 → NP_728562.1 trio, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728562.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7YZA0, Q8T987

Related

FBpp0072542

Conserved Domains (2) summary

cd13241
Location:525 → 655

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

pfam00621
Location:340 → 517

RhoGEF; RhoGEF domain
NM_167850.2 → NP_728563.1 trio, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728563.1

Status: REVIEWED

UniProtKB/TrEMBL

C8VV43, Q8IRI4

Related

FBpp0072543

Conserved Domains (2) summary

cd13241
Location:265 → 395

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

pfam00621
Location:80 → 257

RhoGEF; RhoGEF domain
NM_206228.2 → NP_995950.1 trio, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995950.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7YZA0, Q8T987

Conserved Domains (2) summary

cd13241
Location:525 → 655

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

pfam00621
Location:340 → 517

RhoGEF; RhoGEF domain
NM_001414065.1 → NP_001401024.1 trio, isoform G [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A9F2H0X5