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    glu gluon [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35001, updated on 17-Dec-2024

    Summary

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    Official Symbol
    gluprovided by FlyBase
    Official Full Name
    gluonprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015391
    Locus tag
    Dmel_CG11397
    See related
    AllianceGenome:FB:FBgn0015391
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.156; BcDNA.LD20207; BcDNA:LD20207; CG11397; Dmel\CG11397; DmSMC4; DmSMC4/gluon; dSMC4; Glu; Gluon; l(2)k08819; Smc4; SMC4
    Summary
    Predicted to enable chromatin binding activity. Predicted to contribute to ATP hydrolysis activity. Involved in chromosome separation and mitotic chromosome condensation. Located in chromatin; cytoplasm; and nucleus. Part of condensin complex. Colocalizes with condensed chromosome. Is expressed in embryonic neuroblast; organism; and sensory mother cell. Orthologous to human SMC4 (structural maintenance of chromosomes 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See glu in Genome Data Viewer
    Location:
    36A12-36A13; 2-52 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16733617..16738388, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16733617..16738388, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene tRNA splicing endonuclease subunit 2 Neighboring gene uncharacterized protein Neighboring gene Proteasome beta4 subunit Neighboring gene NUBP iron-sulfur cluster assembly factor 1 Neighboring gene Chitin and LDLR binding deacetylase 3 Neighboring gene Like Sm 7 Neighboring gene Bub3 interacting GLEBS and Zinc finger domain protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A role for Drosophila SMC4 in the resolution of sister chromatids in mitosis. Steffensen S, et al. Curr Biol, 2001 Mar 6. PMID 11267866
    2. Condensin II promotes the formation of chromosome territories by inducing axial compaction of polyploid interphase chromosomes. Bauer CR, et al. PLoS Genet, 2012. PMID 22956908, Free PMC Article
    3. Chromosome condensation: packaging the genome. Uhlmann F. Curr Biol, 2001 May 15. PMID 11378401
    4. Chromosome alignment and transvection are antagonized by condensin II. Hartl TA, et al. Science, 2008 Nov 28. PMID 19039137
    5. Condensin II resolves chromosomal associations to enable anaphase I segregation in Drosophila male meiosis. Hartl TA, et al. PLoS Genet, 2008 Oct. PMID 18927632, Free PMC Article

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ATP hydrolysis activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP hydrolysis activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome separation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ventral cord development HMP PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with condensed chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of condensin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of condensin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of condensin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gluon
    Names
    CG11397-PA
    glu-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16733617..16738388 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165180.2 → NP_723996.1  gluon [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723996.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U6I2, Q9V3A7
      Related
      FBpp0080489
      Conserved Domains (4) summary
      cd03274
      Location:1196 → 1290
      ABC_SMC4_euk; ATP-binding cassette domain of eukaryotic SMC4 proteins
      smart00968
      Location:618 → 733
      SMC_hinge; SMC proteins Flexible Hinge Domain
      COG1196
      Location:89 → 1281
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl21478
      Location:825 → 904
      ATP-synt_B; ATP synthase B/B' CF(0)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q961A5 Q961A5
    Q9U6I2 Q9U6I2
    Q9U9P6 Q9U9P6
    Q9V3A7 Q9V3A7

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