Hex-t1 Hexokinase testis 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hex-t1provided by FlyBase
Official Full Name: Hexokinase testis 1provided by FlyBase
Primary source: FLYBASE:FBgn0042711
Locus tag: Dmel_CG33102
See related: AllianceGenome:FB:FBgn0042711
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG33102; CG5443; CG54430; DHK-453; Dmel\CG33102; Hex; Hex-T1; HEX-t1; HK
Summary: Predicted to enable fructokinase activity and glucokinase activity. Predicted to be involved in canonical glycolysis; glucose 6-phosphate metabolic process; and intracellular glucose homeostasis. Predicted to be active in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in artery disease (multiple); glucose metabolism disease (multiple); obesity; and retinitis pigmentosa. Orthologous to several human genes including GCK (glucokinase); HK2 (hexokinase 2); and HK3 (hexokinase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (26449079..26450585)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (22274801..22276307)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables D-glucose binding	IEA Inferred from Electronic Annotation more info
enables fructokinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucokinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hexokinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in canonical glycolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glucose 6-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose 6-phosphate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glucose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular glucose homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular glucose homeostasis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

NP_788744.1

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain