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    coil coilin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35785, updated on 9-Dec-2024

    Summary

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    Official Symbol
    coilprovided by FlyBase
    Official Full Name
    coilinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033265
    Locus tag
    Dmel_CG8710
    See related
    AllianceGenome:FB:FBgn0033265
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8710; Coilin; Dmel\CG8710
    Summary
    Involved in Cajal body organization. Located in Cajal body and histone locus body. Is expressed in several structures, including adult gut; adult muscle system; epithelial tube; germline cell; and gland. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See coil in Genome Data Viewer
    Location:
    44B3-44B3; 2-58 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8124981..8127242, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4012486..4014747, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene under-developed Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain Neighboring gene Nucleoporin 50kD Neighboring gene Suppressor of Cytokine Signaling at 44A Neighboring gene uncharacterized protein Neighboring gene PSEA-binding protein 49kD Neighboring gene Pabp2 Neighboring gene Odorant-binding protein 44a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cajal bodies and histone locus bodies in Drosophila and Xenopus. Nizami ZF, et al. Cold Spring Harb Symp Quant Biol, 2010. PMID 21047905
    2. Myc localizes to histone locus bodies during replication in Drosophila. Daneshvar K, et al. PLoS One, 2011. PMID 21886841, Free PMC Article
    3. Strategies for gene disruption in Drosophila. Lin SC, et al. Cell Biosci, 2014. PMID 25364499, Free PMC Article
    4. Genetic analysis of nuclear bodies: from nondeterministic chaos to deterministic order. Rajendra TK, et al. Cold Spring Harb Symp Quant Biol, 2010. PMID 21467138, Free PMC Article
    5. Poly (ADP-ribose) polymerase 1 is required for protein localization to Cajal body. Kotova E, et al. PLoS Genet, 2009 Feb. PMID 19229318, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Coiled, a member of the leukocyte antigen 6 (Ly6) family, is crucial for septate junction formation and blood-brain barrier integrity.
      Title: The CD59 family member Leaky/Coiled is required for the establishment of the blood-brain barrier in Drosophila.
    2. coilin is required for normal Cajal body organization in Drosophila but is not essential for viability or production of functional gametes
      Title: Coilin is essential for Cajal body organization in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in Cajal body organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Cajal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in histone locus body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    coilin
    Names
    CG8710-PD
    CG8710-PE
    coil-PD
    coil-PE
    dcoilin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8124981..8127242 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299255.1 → NP_001286184.1  coilin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286184.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LEV8
      Conserved Domains (1) summary
      pfam15862
      Location:8 → 125
      Coilin_N; Coilin N-terminus

    2. NM_001014505.2 → NP_001014505.1  coilin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014505.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z7A8, A1Z7A9, Q8MSN4, Q95SB3
      Conserved Domains (1) summary
      pfam15862
      Location:8 → 125
      Coilin_N; Coilin N-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LEV8 A0A0B4LEV8
    A1Z7A8.1 A1Z7A8

    Gene LinkOut

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