U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    numb numb [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34263, updated on 27-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    numbprovided by FlyBase
    Official Full Name
    numbprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002973
    Locus tag
    Dmel_CG3779
    See related
    AllianceGenome:FB:FBgn0002973
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3779; d-numb; Dmel\CG3779; dNumb; l(2)03235; l(2)3235; l(2)s2201; N7-1; nb; Nb; Numb; NUMB; numbs
    Summary
    Enables Notch binding activity. Involved in several processes, including Malpighian tubule tip cell differentiation; negative regulation of macromolecule metabolic process; and neurogenesis. Located in cell cortex. Is expressed in several structures, including Malpighian tubule tip cell primordium; VUM4 interneuron; anlage in statu nascendi; epithelium; and somatic precursor cell. Used to study brain cancer. Orthologous to several human genes including NUMB (NUMB endocytic adaptor protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See numb in Genome Data Viewer
    Location:
    30B3-30B5; 2-35 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9437469..9464184)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9437469..9464184)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene scattered Neighboring gene Ribosomal protein S28-like Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43769 Neighboring gene GDP dissociation inhibitor

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. High-affinity binding of the Drosophila Numb phosphotyrosine-binding domain to peptides containing a Gly-Pro-(p)Tyr motif. Li SC, et al. Proc Natl Acad Sci U S A, 1997 Jul 8. PMID 9207069, Free PMC Article
    2. Cell fate determination. When is a determinant a determinant? Cohen S, et al. Curr Biol, 1994 May 1. PMID 7922356
    3. Reducing the expression of the Numb adaptor protein in neurons increases the searching behavior of Drosophila larvae. Galbraith A, et al. MicroPubl Biol, 2021. PMID 34327314, Free PMC Article
    4. NIP/DuoxA is essential for Drosophila embryonic development and regulates oxidative stress response. Xie X, et al. Int J Biol Sci, 2010 May 11. PMID 20567495, Free PMC Article
    5. An unequal split. Altman J. Trends Neurosci, 1996 Feb. PMID 8820864

    See all (555) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Paths and pathways that generate cell-type heterogeneity and developmental progression in hematopoiesis.
      Title: Paths and pathways that generate cell-type heterogeneity and developmental progression in hematopoiesis.
    2. Numb levels are upregulated to reinforce the bias of Notch signaling activation in the R3/R4 pair, two post-mitotic cells that are not specified by asymmetric cell division.
      Title: Regulation of Numb during planar cell polarity establishment in the Drosophila eye.
    3. condensed Numb and Pon complex has roles in phase transition during Drosophila neuroblast asymmetric division
      Title: Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division.
    4. Inscuteable maintains type I neuroblast lineage identity via Numb/Notch signaling in the Drosophila larval brain
      Title: Inscuteable maintains type I neuroblast lineage identity via Numb/Notch signaling in the Drosophila larval brain.
    5. Data suggest that Numb controls the balance between Notch receptor recycling and receptor targeting to late endosomes to regulate signaling output after asymmetric cell division in Drosophila neural progenitors.
      Title: Numb regulates the balance between Notch recycling and late-endosome targeting in Drosophila neural progenitor cells.
    6. The authors find that Numb is regulated in part through its asymmetric and symmetric distribution during stem cell divisions; however, its de novo synthesis is also required during the differentiation of the enteroendocrine cells.
      Title: Intrinsic regulation of enteroendocrine fate by Numb.
    7. Spdo is sorted toward late endosomes in a Numb-dependent manner.
      Title: A fluorescent tagging approach in Drosophila reveals late endosomal trafficking of Notch and Sanpodo.
    8. Numb inhibits the recycling of Sanpodo in Drosophila sensory organ precursor.
      Title: Numb inhibits the recycling of Sanpodo in Drosophila sensory organ precursor.
    9. Numb localizes at endosomes and controls the endosomal sorting of notch after asymmetric division in Drosophila.
      Title: Numb localizes at endosomes and controls the endosomal sorting of notch after asymmetric division in Drosophila.
    10. Data show regulation of centrosome movements by numb and the collapsin response mediator protein during Drosophila sensory progenitor asymmetric division.
      Title: Regulation of centrosome movements by numb and the collapsin response mediator protein during Drosophila sensory progenitor asymmetric division.
    Submit: New GeneRIF Correction See all GeneRIFs (34)

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables Notch binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Malpighian tubule tip cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in asymmetric neuroblast division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in centrosome localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic heart tube development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in enteroendocrine cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of receptor recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuroblast development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pericardial nephrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of asymmetric cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory organ precursor cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory organ precursor cell fate determination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sensory organ precursor cell fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basal part of cell TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    numb
    Names
    CG3779-PA
    CG3779-PB
    CG3779-PD
    d-Numb
    numb-PA
    numb-PB
    numb-PD

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9437469..9464184
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164855.2 → NP_723460.1  numb, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723460.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P16554
      Related
      FBpp0079419
      Conserved Domains (2) summary
      cd01268
      Location:26 → 160
      PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
      pfam06311
      Location:228 → 333
      NumbF; NUMB domain

    2. NM_001273362.1 → NP_001260291.1  numb, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260291.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B8A413, B8A419, P16554, Q8IPE9, Q961A6, Q9VLB8
      UniProtKB/TrEMBL
      M9PCN6
      Conserved Domains (2) summary
      cd01268
      Location:67 → 201
      PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
      pfam06311
      Location:269 → 374
      NumbF; NUMB domain

    3. NM_078799.3 → NP_523523.2  numb, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523523.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B8A413, B8A419, P16554, Q8IPE9, Q961A6, Q9VLB8
      UniProtKB/TrEMBL
      M9PCN6
      Related
      FBpp0079420
      Conserved Domains (2) summary
      cd01268
      Location:67 → 201
      PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
      pfam06311
      Location:269 → 374
      NumbF; NUMB domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PCN6 M9PCN6
    P16554.2 P16554

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools