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    Sodq Sodesque [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43133, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sodqprovided by FlyBase
    Official Full Name
    Sodesqueprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039386
    Locus tag
    Dmel_CG5948
    See related
    AllianceGenome:FB:FBgn0039386
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5948; Dmel\CG5948; SOD
    Summary
    Predicted to enable copper ion binding activity. Predicted to be involved in superoxide metabolic process. Human ortholog(s) of this gene implicated in several diseases, including coronary artery disease (multiple); diabetes mellitus (multiple); diabetic retinopathy; lung disease (multiple); and polyneuropathy. Orthologous to human SOD3 (superoxide dismutase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sodq in Genome Data Viewer
    Location:
    96F6-96F7; 3-89 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25895822..25897174)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21721544..21722896)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Lnk Neighboring gene uncharacterized protein Neighboring gene Multicopper oxidase 3 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Superoxide dismutase evolution and life span regulation. Landis GN, et al. Mech Ageing Dev, 2005 Mar. PMID 15664623
    2. Distribution and diversity of ROS-generating enzymes across the animal kingdom, with a focus on sponges (Porifera). Hewitt OH, et al. BMC Biol, 2022 Sep 30. PMID 36175868, Free PMC Article
    3. Meta-Analysis of Grainyhead-Like Dependent Transcriptional Networks: A Roadmap for Identifying Novel Conserved Genetic Pathways. Mathiyalagan N, et al. Genes (Basel), 2019 Oct 31. PMID 31683705, Free PMC Article
    4. Fatty acid tryptamide from cacao elongates Drosophila melanogaster lifespan with sirtuin-dependent heat shock protein expression. Kanno K, et al. Sci Rep, 2022 Jul 15. PMID 35840713, Free PMC Article
    5. Genome-wide patterns of latitudinal differentiation among populations of Drosophila melanogaster from North America. Fabian DK, et al. Mol Ecol, 2012 Oct. PMID 22913798, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables superoxide dismutase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables superoxide dismutase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in superoxide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sodesque
    Names
    CG5948-PA
    CG5948-PB
    Sodq-PA
    Sodq-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25895822..25897174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143183.2 → NP_651440.1  sodesque, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651440.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VBK8
      Related
      FBpp0084313
      Conserved Domains (1) summary
      pfam00080
      Location:108 → 243
      Sod_Cu; Copper/zinc superoxide dismutase (SODC)

    2. NM_001260377.1 → NP_001247306.1  sodesque, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247306.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K763
      Conserved Domains (1) summary
      pfam00080
      Location:107 → 242
      Sod_Cu; Copper/zinc superoxide dismutase (SODC)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K763 A0A0B4K763
    Q9VBK8 Q9VBK8

    Gene LinkOut

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