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    Spn43Aa Serpin 43Aa [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45041, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spn43Aaprovided by FlyBase
    Official Full Name
    Serpin 43Aaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024294
    Locus tag
    Dmel_CG12172
    See related
    AllianceGenome:FB:FBgn0024294
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118057.1; CG12172; Dmel\CG12172; Ser1; SER1; Spn43 Aa; Spn43A
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of proteolysis. Located in cytoplasm. Is expressed in several structures, including clypeo-labral primordium; dorsal epidermis primordium; embryonic salivary gland duct; epithelium; and salivary gland common duct primordium. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive nonsyndromic deafness 91; intermediate coronary syndrome; neurodegenerative disease (multiple); thrombophilia (multiple); and toxic shock syndrome. Orthologous to several human genes including SERPINA12 (serpin family A member 12); SERPINB1 (serpin family B member 1); and SERPINB6 (serpin family B member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Spn43Aa in Genome Data Viewer
    Location:
    42F2-42F3; 2-55 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7147692..7149289)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3035197..3036794)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44443 Neighboring gene Cytochrome P450 9b2 Neighboring gene long non-coding RNA:CR44200 Neighboring gene uncharacterized protein Neighboring gene Serpin 43Ab Neighboring gene prickle

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Airway specific deregulation of asthma-related serpins impairs tracheal architecture and oxygenation in D. melanogaster. Ehrhardt B, et al. Sci Rep, 2024 Jul 17. PMID 39019933, Free PMC Article
    2. The necrotic gene in Drosophila corresponds to one of a cluster of three serpin transcripts mapping at 43A1.2. Green C, et al. Genetics, 2000 Nov. PMID 11063688, Free PMC Article
    3. The balance between isoforms of the prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs. Gubb D, et al. Genes Dev, 1999 Sep 1. PMID 10485852, Free PMC Article
    4. Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila. Levashina EA, et al. Science, 1999 Sep 17. PMID 10489372
    5. The Drosophila serpins: multiple functions in immunity and morphogenesis. Reichhart JM, et al. Methods Enzymol, 2011. PMID 21683256

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serpin 43Aa
    Names
    CG12172-PA
    Spn43Aa-PA
    serine protease inhibitor 1
    serine protease inhibitor 43Aa

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7147692..7149289
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080066.3 → NP_524805.1  serpin 43Aa [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524805.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KA66, Q8MQZ7
      Related
      FBpp0088112
      Conserved Domains (1) summary
      cd00172
      Location:28 → 387
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KA66 Q7KA66
    Q8MQZ7 Q8MQZ7

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