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    dgo diego [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36139, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dgoprovided by FlyBase
    Official Full Name
    diegoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086898
    Locus tag
    Dmel_CG12342
    See related
    AllianceGenome:FB:FBgn0086898
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12342; Dgo; DGO; Dmel\CG12342; EP(2)2619; EP2619
    Summary
    Involved in establishment of imaginal disc-derived wing hair orientation and ommatidial rotation. Predicted to be located in cytoplasm. Orthologous to human ANKRD6 (ankyrin repeat domain 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dgo in Genome Data Viewer
    Location:
    47C1-47C1; 2-63 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10816037..10819884, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6703542..6707389, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Methyl methanesulfonate sensitivity 4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Proteasome beta5 subunit Neighboring gene Lsm10 Neighboring gene Ribosomal protein S15Ab

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ankyrin repeat protein Diego mediates Frizzled-dependent planar polarization. Feiguin F, et al. Dev Cell, 2001 Jul. PMID 11703927
    2. Mutations associated with human neural tube defects display disrupted planar cell polarity in Drosophila. Humphries AC, et al. Elife, 2020 Apr 1. PMID 32234212, Free PMC Article
    3. Wnt-Frizzled/planar cell polarity signaling: cellular orientation by facing the wind (Wnt). Yang Y, et al. Annu Rev Cell Dev Biol, 2015. PMID 26566118, Free PMC Article
    4. Role of cell polarity and planar cell polarity (PCP) proteins in spermatogenesis. Li L, et al. Crit Rev Biochem Mol Biol, 2020 Feb. PMID 32207344
    5. The Frizzled Planar Cell Polarity signaling pathway controls Drosophila wing topography. Doyle K, et al. Dev Biol, 2008 May 1. PMID 18384764

    See all (115) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results indicated that mAnkrd6 is a functional homolog of the Drosophila diego gene for mammalian planar cell polarity (PCP) regulation.
      Title: Ankrd6 is a mammalian functional homolog of Drosophila planar cell polarity gene diego and regulates coordinated cellular orientation in the mouse inner ear.
    2. the initial membrane association of Dgo depends on Fz, and that Dgo physically interacts with Strabismus and prickle through its Ankyrin repeats
      Title: Diego interacts with Prickle and Strabismus/Van Gogh to localize planar cell polarity complexes.
    3. demonstrate that Diversin and Dishevelled function together in a mutually dependent fashion in zebrafish gastrulation and organ formation
      Title: Diversin regulates heart formation and gastrulation movements in development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chloroplast targeting sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in establishment of imaginal disc-derived wing hair orientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of ommatidial planar polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in establishment of ommatidial planar polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ommatidial rotation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to chloroplast IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    diego
    Names
    CG12342-PA
    CG12342-PB
    EP2619
    dgo-PA
    dgo-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10816037..10819884 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136770.2 → NP_610614.1  diego, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610614.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JUF2
      Related
      FBpp0087344
      Conserved Domains (3) summary
      cd00204
      Location:126 → 249
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:135 → 227
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:130 → 161
      ANK; ANK repeat [structural motif]

    2. NM_165800.2 → NP_724973.1  diego, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724973.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JUF2
      Related
      FBpp0087345
      Conserved Domains (3) summary
      cd00204
      Location:126 → 249
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:135 → 227
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:130 → 161
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JUF2 Q7JUF2

    Gene LinkOut

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