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    CG5877 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32455, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5877provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030625
    Locus tag
    Dmel_CG5877
    See related
    AllianceGenome:FB:FBgn0030625
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG5877
    Summary
    Predicted to be involved in negative regulation of RNA catabolic process and regulatory ncRNA-mediated heterochromatin formation. Part of catalytic step 2 spliceosome. Orthologous to human NRDE2 (NRDE-2, necessary for RNA interference, domain containing). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5877 in Genome Data Viewer
    Location:
    13B4-13B5; 1-50 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15293031..15297169)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15187064..15191202)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44663 Neighboring gene long non-coding RNA:CR44664 Neighboring gene antisense RNA:CR44429 Neighboring gene germ cell-expressed bHLH-PAS Neighboring gene antisense RNA:CR44961

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic analyses of Drosophila melanogaster models of chromatin modification disorders. MacPherson RA, et al. Genetics, 2023 Aug 9. PMID 37036413, Free PMC Article
    2. Evolutionary divergence of the paralogs Methoprene tolerant (Met) and germ cell expressed (gce) within the genus Drosophila. Baumann A, et al. J Insect Physiol, 2010 Oct. PMID 20457161
    3. Testing Implications of the Omnigenic Model for the Genetic Analysis of Loci Identified through Genome-wide Association. Zhang W, et al. Curr Biol, 2021 Mar 8. PMID 33417882
    4. The mRNA transportome of the BicD/Egl transport machinery. Vazquez-Pianzola P, et al. RNA Biol, 2017 Jan 2. PMID 27801632, Free PMC Article
    5. Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. Herold N, et al. Mol Cell Biol, 2009 Jan. PMID 18981222, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in negative regulation of RNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulatory ncRNA-mediated heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5877-PA
    CG5877-PB
    CG5877-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15293031..15297169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132786.4 → NP_573014.2  uncharacterized protein Dmel_CG5877, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573014.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXW9
      Related
      FBpp0073818
      Conserved Domains (1) summary
      pfam08424
      Location:180 → 348
      NRDE-2; NRDE-2, necessary for RNA interference

    2. NM_001272634.2 → NP_001259563.2  uncharacterized protein Dmel_CG5877, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259563.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXW9
      Conserved Domains (1) summary
      pfam08424
      Location:180 → 348
      NRDE-2; NRDE-2, necessary for RNA interference

    3. NM_167434.3 → NP_727839.2  uncharacterized protein Dmel_CG5877, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727839.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IR40, Q8T048
      Related
      FBpp0073819
      Conserved Domains (1) summary
      pfam08424
      Location:1 → 95
      NRDE-2; NRDE-2, necessary for RNA interference
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IR40 Q8IR40
    Q8T048 Q8T048
    Q9VXW9 Q9VXW9

    Gene LinkOut

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