Gos28 Golgi SNARE, 28 kDa [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Gos28provided by FlyBase
Official Full Name: Golgi SNARE, 28 kDaprovided by FlyBase
Primary source: FLYBASE:FBgn0044871
Locus tag: Dmel_CG7700
See related: AllianceGenome:FB:FBgn0044871
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7700; dgos28; dGos28; Dmel\CG7700; FSG28; gos28; GOS28
Summary: Enables SNAP receptor activity. Involved in inter-Golgi cisterna vesicle-mediated transport. Located in membrane. Is expressed in adult head. Used to study neurodegenerative disease. Orthologous to human GOSR1 (golgi SNAP receptor complex member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (18663738..18665307)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (14489460..14491029)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Data indicate that mutations in Golgi SNARE protein gos28 lead to defective rhodopsin (Rh1) trafficking.
Title: The Gos28 SNARE protein mediates intra-Golgi transport of rhodopsin and is required for photoreceptor survival.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNAP receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables SNAP receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Golgi vesicle transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in inter-Golgi cisterna vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in inter-Golgi cisterna vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intra-Golgi vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Golgi medial cisterna	IBA Inferred from Biological aspect of Ancestor more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi trans cisterna	ISS Inferred from Sequence or Structural Similarity more info
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SNARE complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cis-Golgi network	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed