disco disconnected [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: discoprovided by FlyBase
Official Full Name: disconnectedprovided by FlyBase
Primary source: FLYBASE:FBgn0000459
Locus tag: Dmel_CG9908
See related: AllianceGenome:FB:FBgn0000459
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9908; disc; Disco; DISCO; Dmel\CG9908
Summary: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including eclosion rhythm; leg disc proximal/distal pattern formation; and locomotor rhythm. Located in nucleus. Is expressed in several structures, including anlage in statu nascendi; anterior-posterior subdivision of organism; ganglia; gut section; and imaginal disc. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 16. Orthologous to human BNC1 (basonuclin zinc finger protein 1) and BNC2 (basonuclin zinc finger protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (16210598..16216750, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (16104631..16110783, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Disco plays a fundamental role in the Dll-dependent patterning of antenna and leg, perhaps as a regulator of Dll gene expression.
Title: Mutual regulation of the Drosophila disconnected (disco) and Distal-less (Dll) genes contributes to proximal-distal patterning of antenna and leg.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in antennal development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian rhythm	NAS Non-traceable Author Statement more info	PubMed
involved_in eclosion rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leg disc proximal/distal pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell maintenance	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed