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    Adck5 aarF domain containing kinase 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39260, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adck5provided by FlyBase
    Official Full Name
    aarF domain containing kinase 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0036142
    Locus tag
    Dmel_CG7616
    See related
    AllianceGenome:FB:FBgn0036142
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7616; dADCK5; Dmel\CG7616; FBgn 36142
    Summary
    Predicted to be involved in lipid homeostasis and mitochondrion organization. Predicted to be located in mitochondrial inner membrane. Is expressed in adult head. Orthologous to human ADCK5 (aarF domain containing kinase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Adck5 in Genome Data Viewer
    Location:
    68A9-68A9; 3-34 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11169817..11172411)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11162917..11165511)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene ALG10 alpha-1,2-glucosyltransferase Neighboring gene wntless Neighboring gene uncharacterized protein Neighboring gene Glucuronyltransferase P

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of Aarf domain-containing kinase 1 in Drosophila melanogaster. Wisidagama DR, et al. Dev Dyn, 2019 Sep. PMID 31175694, Free PMC Article
    2. Drosophila ADCK1 is critical for maintaining mitochondrial structures and functions in the muscle. Yoon W, et al. PLoS Genet, 2019 May. PMID 31125351, Free PMC Article
    3. Sprinter: a novel transmembrane protein required for Wg secretion and signaling. Goodman RM, et al. Development, 2006 Dec. PMID 17108000
    4. Mammalian and Invertebrate Models as Complementary Tools for Gaining Mechanistic Insight on Muscle Responses to Spaceflight. Cahill T, et al. Int J Mol Sci, 2021 Aug 31. PMID 34502375, Free PMC Article
    5. Filtering of Data-Driven Gene Regulatory Networks Using Drosophila melanogaster as a Case Study. Cuesta-Astroz Y, et al. Front Genet, 2021. PMID 34394179, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in lipid homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    aarF domain containing kinase 5
    Names
    Adck5-PA
    Adck5-PB
    CG7616-PA
    CG7616-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11169817..11172411
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140189.3 → NP_648446.1  aarF domain containing kinase 5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648446.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B0BNN6, Q9VTG5
      Related
      FBpp0075892
      Conserved Domains (2) summary
      COG0661
      Location:98 → 469
      AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
      cd13969
      Location:144 → 395
      ADCK1-like; aarF domain containing kinase 1 and similar proteins

    2. NM_001274776.1 → NP_001261705.1  aarF domain containing kinase 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261705.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B0BNN6, Q9VTG5
      Conserved Domains (2) summary
      COG0661
      Location:98 → 469
      AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
      cd13969
      Location:144 → 395
      ADCK1-like; aarF domain containing kinase 1 and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VTG5 Q9VTG5

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