Mdh2 Malate dehydrogenase 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mdh2provided by FlyBase
Official Full Name: Malate dehydrogenase 2provided by FlyBase
Primary source: FLYBASE:FBgn0262559
Locus tag: Dmel_CG7998
See related: AllianceGenome:FB:FBgn0262559
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG 7998; CG7998; Dmel\CG7998; l(3)psg7; Mdh; MDH-2; mdh2; MDH2; mMdh; psg7
Summary: Enables L-malate dehydrogenase (NAD+) activity. Involved in several processes, including autophagic cell death; instar larval or pupal development; and tricarboxylic acid cycle. Located in mitochondrion. Is expressed in several structures, including adult brain; adult brain cell body rind; adult head; adult heart; and germline cell. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 51. Orthologous to human MDH2 (malate dehydrogenase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 90F8-90F9; 3-62 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (18226396..18228718)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (14052118..14054440)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables L-malate dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-malate dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables L-malate dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables malate dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in NADH metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in autophagic cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in gluconeogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in larval midgut cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in malate metabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in malate-aspartate shuttle	ISS Inferred from Sequence or Structural Similarity more info
involved_in oxaloacetate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pupal development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in salivary gland histolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: malate dehydrogenase 2

Names: CG7998-PA; L-Malate dehydrogenase; Mdh2-PA; lethal (3) persistent salivary gland 7; malate dehydrogenase; malate dehydrogenase (mitochondrial); malic DH; mitochondrial malate dehydrogenase; mitochondrial-Mdh

NP_650696.1

EC 1.-.-.-

EC 1.1.1.-

EC 1.1.1.37

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

18226396..18228718

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_142439.3 → NP_650696.1 malate dehydrogenase 2 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_650696.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VEB1

Related

FBpp0082985

Conserved Domains (1) summary

cd01337
Location:25 → 334

MDH_glyoxysomal_mitochondrial; Glyoxysomal and mitochondrial malate dehydrogenases