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    KLF11 KLF transcription factor 11 [ Homo sapiens (human) ]

    Gene ID: 8462, updated on 10-Dec-2024

    Summary

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    Official Symbol
    KLF11provided by HGNC
    Official Full Name
    KLF transcription factor 11provided by HGNC
    Primary source
    HGNC:HGNC:11811
    See related
    Ensembl:ENSG00000172059 MIM:603301; AllianceGenome:HGNC:11811
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FKLF; FKLF1; MODY7; TIEG2; Tieg3
    Summary
    The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
    Expression
    Ubiquitous expression in testis (RPKM 20.2), lung (RPKM 12.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See KLF11 in Genome Data Viewer
    Location:
    2p25.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (10043550..10054836)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (10072326..10083576)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (10183677..10194963)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene KLF11-I enhancer Neighboring gene uncharacterized LOC112268412 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:10170473-10170643 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10173619-10174119 Neighboring gene KLF11 promoter region Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11151 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11152 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11153 Neighboring gene KLF11 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10185594-10186333 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10188595-10189095 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:10197717-10198660 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:10198661-10199603 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10200462-10201324 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10201325-10202185 Neighboring gene cystin 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10203342-10203940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10203941-10204538 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10204790-10205668 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10205669-10206546 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10211417-10211918 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11154 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11155 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11156 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15296 Neighboring gene uncharacterized LOC124900536

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Human TIEG2/KLF11 induces oligodendroglial cell death by downregulation of Bcl-XL expression. Wang Z, et al. J Neural Transm (Vienna), 2007 Jul. PMID 17308981
    2. Krüppel-like factor 11 regulates the expression of metabolic genes via an evolutionarily conserved protein interaction domain functionally disrupted in maturity onset diabetes of the young. Lomberk G, et al. J Biol Chem, 2013 Jun 14. PMID 23589285, Free PMC Article
    3. The expression of KLF11 (TIEG2), a monoamine oxidase B transcriptional activator in the prefrontal cortex of human alcohol dependence. Udemgba C, et al. Alcohol Clin Exp Res, 2014 Jan. PMID 23915421, Free PMC Article
    4. Human Krüppel-like factor 11 differentially regulates human insulin promoter activity in β-cells and non-β-cells via p300 and PDX1 through the regulatory sites A3 and CACCC box. Perakakis N, et al. Mol Cell Endocrinol, 2012 Nov 5. PMID 22801105
    5. Single and combinatorial chromatin coupling events underlies the function of transcript factor Krüppel-like factor 11 in the regulation of gene networks. Calvo E, et al. BMC Mol Biol, 2014 May 25. PMID 24885560, Free PMC Article

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aberrant cell adhesiveness due to DNA hypermethylation of KLF11 in papillary urothelial carcinomas.
      Title: Aberrant cell adhesiveness due to DNA hypermethylation of KLF11 in papillary urothelial carcinomas.
    2. Maturity-onset diabetes of the young type 7 (MODY7) and mutation in the Kruppel-like transcription factor 11 (KLF11) gene.
      Title: Maturity-onset diabetes of the young type 7 (MODY7) and mutation in the Krüppel-like transcription factor 11 (KLF11) gene.
    3. Maturity-onset Diabetes of the Young Type 7 (MODY7) and the Kruppellike Factor 11 Mutation (KLF11). A Review.
      Title: Maturity-onset Diabetes of the Young Type 7 (MODY7) and the Krüppellike Factor 11 Mutation (KLF11). A Review.
    4. KLF11 regulates lung adenocarcinoma ferroptosis and chemosensitivity by suppressing GPX4.
      Title: KLF11 regulates lung adenocarcinoma ferroptosis and chemosensitivity by suppressing GPX4.
    5. Genetic and Functional Analyses of the Novel KLF11 Pro193Thr Variant in a Three-Generation Family with MODY7.
      Title: Genetic and Functional Analyses of the Novel KLF11 Pro193Thr Variant in a Three-Generation Family with MODY7.
    6. Endothelial KLF11 as a Nephroprotectant in AKI.
      Title: Endothelial KLF11 as a Nephroprotectant in AKI.
    7. KLF11 Is a Novel Endogenous Protectant against Renal Ischemia-Reperfusion Injury.
      Title: KLF11 Is a Novel Endogenous Protectant against Renal Ischemia-Reperfusion Injury.
    8. A novel KLF11 variant in a family with maturity-onset diabetes of the young.
      Title: A novel KLF11 variant in a family with maturity-onset diabetes of the young.
    9. KLF11 promotes the progression of glioma via regulating Holliday junction recognition protein.
      Title: KLF11 promotes the progression of glioma via regulating Holliday junction recognition protein.
    10. KLF11 Protects against Venous Thrombosis via Suppressing Tissue Factor Expression.
      Title: KLF11 Protects against Venous Thrombosis via Suppressing Tissue Factor Expression.
    Submit: New GeneRIF Correction See all GeneRIFs (58)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to peptide IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of regulation of G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Krueppel-like factor 11
    Names
    Kruppel like factor 11
    TGFB-inducible early growth response protein 2
    TIEG-2
    transforming growth factor-beta-inducible early growth response protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_017199.2 RefSeqGene

      Range
      5002..16288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001177716.2 → NP_001171187.1  Krueppel-like factor 11 isoform b

      See identical proteins and their annotated locations for NP_001171187.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC104794
      Consensus CDS
      CCDS54333.1
      UniProtKB/TrEMBL
      B7ZAX4
      Related
      ENSP00000444690.1, ENST00000540845.5
      Conserved Domains (4) summary
      COG5048
      Location:376 → 432
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:382 → 401
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:437 → 459
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:423 → 446
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001177718.2 → NP_001171189.1  Krueppel-like factor 11 isoform b

      See identical proteins and their annotated locations for NP_001171189.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC104794
      Consensus CDS
      CCDS54333.1
      UniProtKB/TrEMBL
      B7ZAX4
      Related
      ENSP00000442722.1, ENST00000535335.1
      Conserved Domains (4) summary
      COG5048
      Location:376 → 432
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:382 → 401
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:437 → 459
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:423 → 446
      zf-H2C2_2; Zinc-finger double domain

    3. NM_003597.5 → NP_003588.1  Krueppel-like factor 11 isoform a

      See identical proteins and their annotated locations for NP_003588.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC104794
      Consensus CDS
      CCDS1668.1
      UniProtKB/Swiss-Prot
      B4DZE7, O14901, Q9EPF4
      UniProtKB/TrEMBL
      B2RCZ6, Q53QU8
      Related
      ENSP00000307023.1, ENST00000305883.6
      Conserved Domains (4) summary
      COG5048
      Location:393 → 449
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:399 → 418
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:454 → 476
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:440 → 463
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      10043550..10054836
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047446025.1 → XP_047301981.1  Krueppel-like factor 11 isoform X1

      UniProtKB/TrEMBL
      B7ZAX4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      10072326..10083576
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344204.1 → XP_054200179.1  Krueppel-like factor 11 isoform X1

      UniProtKB/TrEMBL
      B7ZAX4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O14901.2 GenPept UniProtKB/Swiss-Prot:O14901

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools