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    MAGEA10 MAGE family member A10 [ Homo sapiens (human) ]

    Gene ID: 4109, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MAGEA10provided by HGNC
    Official Full Name
    MAGE family member A10provided by HGNC
    Primary source
    HGNC:HGNC:6797
    See related
    Ensembl:ENSG00000124260 MIM:300343; AllianceGenome:HGNC:6797
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT1.10; MAGE10
    Summary
    This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream melanoma antigen family A, 5 (MAGEA5) gene.[provided by RefSeq, Oct 2011]
    Expression
    Biased expression in placenta (RPKM 4.9) and testis (RPKM 1.2) See more
    Orthologs
    mouse all
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    Genomic context

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    See MAGEA10 in Genome Data Viewer
    Location:
    Xq28
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (152133310..152138577, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (150399374..150404642, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (151301782..151307049, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein SA pseudogene 60 Neighboring gene uncharacterized LOC105373369 Neighboring gene MAGEA10-MAGEA5 readthrough Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:151297273-151298472 Neighboring gene MAGE family member A5, pseudogene Neighboring gene Sharpr-MPRA regulatory region 4801 Neighboring gene Sharpr-MPRA regulatory region 4725 Neighboring gene gamma-aminobutyric acid type A receptor subunit alpha3 Neighboring gene RNA, U6 small nuclear 764, pseudogene Neighboring gene microRNA 105-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. How the Intrinsically Disordered N-Terminus of Cancer/Testis Antigen MAGEA10 Is Responsible for Its Expression, Nuclear Localisation and Aberrant Migration. Samel A, et al. Biomolecules, 2023 Nov 24. PMID 38136576, Free PMC Article
    2. MAGEA10 expression is a predictive marker of early hepatic recurrence after curative gastrectomy for gastric and gastroesophageal junction cancer. Fujiya K, et al. Gastric Cancer, 2021 Mar. PMID 32965606
    3. cDNA and protein characterization of human MAGE-10. Rimoldi D, et al. Int J Cancer, 1999 Sep 9. PMID 10446460
    4. Melanoma-associated antigens in esophageal adenocarcinoma: identification of novel MAGE-A10 splice variants. Lin J, et al. Clin Cancer Res, 2004 Sep 1. PMID 15355897
    5. Tissue homing and persistence of defined antigen-specific CD8+ tumor-reactive T-cell clones in long-term melanoma survivors. Le Gal FA, et al. J Invest Dermatol, 2007 Mar. PMID 17039243

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of MAGE A1 to MAGE A10 in the Forceps Biopsy and Bronchoalveolar Lavage Specimens from Patients with the Central Lung Tumor.
      Title: Expression of MAGE A1 to MAGE A10 in the Forceps Biopsy and Bronchoalveolar Lavage Specimens from Patients with the Central Lung Tumor.
    2. How the Intrinsically Disordered N-Terminus of Cancer/Testis Antigen MAGEA10 Is Responsible for Its Expression, Nuclear Localisation and Aberrant Migration.
      Title: How the Intrinsically Disordered N-Terminus of Cancer/Testis Antigen MAGEA10 Is Responsible for Its Expression, Nuclear Localisation and Aberrant Migration.
    3. MAGEA10 expression is a predictive marker of early hepatic recurrence after curative gastrectomy for gastric and gastroesophageal junction cancer.
      Title: MAGEA10 expression is a predictive marker of early hepatic recurrence after curative gastrectomy for gastric and gastroesophageal junction cancer.
    4. CTAs (MAGE-A4, NY-ESO-1, MAGE-A10) were more likely expressed in patients with squamous cell carcinoma of the lung and when CTAs combined with CD133, they can be better prognostic factors.
      Title: Predictive and prognostic effect of CD133 and cancer-testis antigens in stage Ib-IIIA non-small cell lung cancer.
    5. By using Molecular-Docking, 3 MAGEA10 peptides were found binding to the groove position of HLA-A( *)0210 same as MAGEA4 peptide co-crystallized with HLA-A( *)0210, which indicates they could be promising for HLA-A( *)0201 presentation in immunotherapy.
      Title: MAGEA10 gene expression in non-small cell lung cancer and A549 cells, and the affinity of epitopes with the complex of HLA-A(∗)0201 alleles.
    6. We clearly showed that MAGE-A10 is frequently expressed in the group of triple-negative breast cancer patients
      Title: High expression of MAGE-A10 cancer-testis antigen in triple-negative breast cancer.
    7. High MAGE-A10 is associated with lung, skin and urothelial malignancies.
      Title: MAGE-A10 is a nuclear protein frequently expressed in high percentages of tumor cells in lung, skin and urothelial malignancies.
    8. This is the first report of these MAGE-A10 alternative splice sequences, and characterization of MAGE-A expression
      Title: Melanoma-associated antigens in esophageal adenocarcinoma: identification of novel MAGE-A10 splice variants.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC10599

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    melanoma-associated antigen 10
    Names
    MAGE-10 antigen
    cancer/testis antigen 1.10
    cancer/testis antigen family 1, member 10
    melanoma antigen family A, 10
    melanoma antigen family A10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011543.3 → NP_001011543.3  melanoma-associated antigen 10

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC116666
      Consensus CDS
      CCDS14705.1
      UniProtKB/Swiss-Prot
      P43363
      UniProtKB/TrEMBL
      B2RAE8
      Related
      ENSP00000244096.3, ENST00000244096.7
      Conserved Domains (2) summary
      pfam01454
      Location:141 → 306
      MAGE; MAGE family
      pfam12440
      Location:6 → 116
      MAGE_N; Melanoma associated antigen family N terminal

    2. NM_001251828.2 → NP_001238757.2  melanoma-associated antigen 10

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC116666
      Consensus CDS
      CCDS14705.1
      UniProtKB/Swiss-Prot
      P43363
      UniProtKB/TrEMBL
      B2RAE8
      Conserved Domains (2) summary
      pfam01454
      Location:141 → 306
      MAGE; MAGE family
      pfam12440
      Location:6 → 116
      MAGE_N; Melanoma associated antigen family N terminal

    3. NM_021048.5 → NP_066386.3  melanoma-associated antigen 10

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC116666
      Consensus CDS
      CCDS14705.1
      UniProtKB/Swiss-Prot
      P43363
      UniProtKB/TrEMBL
      B2RAE8
      Related
      ENSP00000359347.4, ENST00000370323.9
      Conserved Domains (2) summary
      pfam01454
      Location:141 → 306
      MAGE; MAGE family
      pfam12440
      Location:6 → 116
      MAGE_N; Melanoma associated antigen family N terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      152133310..152138577 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      150399374..150404642 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43363.2 GenPept UniProtKB/Swiss-Prot:P43363

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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