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    RBM34 RNA binding motif protein 34 [ Homo sapiens (human) ]

    Gene ID: 23029, updated on 10-Dec-2024

    Summary

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    Official Symbol
    RBM34provided by HGNC
    Official Full Name
    RNA binding motif protein 34provided by HGNC
    Primary source
    HGNC:HGNC:28965
    See related
    Ensembl:ENSG00000188739 MIM:619915; AllianceGenome:HGNC:28965
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the RNA-binding motif family of RNA recognition motif proteins. The encoded protein contains an RNA-binding domain made up of two RNA recognition motif subdomains referred to as RNA recognition motif-1 and RNA recognition motif-2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
    Expression
    Ubiquitous expression in testis (RPKM 15.6), lymph node (RPKM 10.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RBM34 in Genome Data Viewer
    Location:
    1q42.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (235131183..235161250, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (234522898..234552956, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (235294498..235324565, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2790 Neighboring gene long intergenic non-protein coding RNA 1348 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:235245875-235246397 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:235256647-235257230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2791 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1984 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2792 Neighboring gene uncharacterized LOC105379283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2793 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2794 Neighboring gene translocase of outer mitochondrial membrane 20 Neighboring gene small nucleolar RNA, H/ACA box 14B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2795 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:235322928-235323532 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:235323819-235325018 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:235334884-235335090 Neighboring gene AT-rich interaction domain 4B Neighboring gene microRNA 4753 Neighboring gene Sharpr-MPRA regulatory region 13312 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:235434772-235435360 Neighboring gene ribosomal protein L23a pseudogene 23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Microarray analysis of differentially expressed genes in cells resistant to HIV-1. Kartvelishvili A, et al. Immunol Lett, 2004 Apr 30. PMID 15134903
    2. Functional Networks of Highest-Connected Splice Isoforms: From The Chromosome 17 Human Proteome Project. Li HD, et al. J Proteome Res, 2015 Sep 4. PMID 26216192, Free PMC Article
    3. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. Nagase T, et al. DNA Res, 1995. PMID 7788527
    4. Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping. Lempiäinen JK, et al. Mol Cell Proteomics, 2017 Aug. PMID 28611094, Free PMC Article
    5. Expanding the substantial interactome of NEMO using protein microarrays. Fenner BJ, et al. PLoS One, 2010 Jan 20. PMID 20098747, Free PMC Article

    See all (100) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif downregulates the expression of RNA binding motif protein 34 (RBM34) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0117

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein 34
    Names
    epididymis secretory sperm binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346738.2 → NP_001333667.1  RNA-binding protein 34 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1
      Source sequence(s)
      AK292362, AL133418, AL732292, BM995796, DB045266
      UniProtKB/TrEMBL
      A0A384NL74

    2. NM_015014.4 → NP_055829.2  RNA-binding protein 34 isoform 1

      See identical proteins and their annotated locations for NP_055829.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BC029451, BM995796
      Consensus CDS
      CCDS41477.2
      UniProtKB/Swiss-Prot
      A8K8J7, P42696, Q8N2Z8, Q9H5A1
      UniProtKB/TrEMBL
      A0A384NL74
      Related
      ENSP00000386226.3, ENST00000408888.8
      Conserved Domains (3) summary
      COG0724
      Location:176 → 382
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12394
      Location:185 → 276
      RRM1_RBM34; RNA recognition motif 1 in RNA-binding protein 34 (RBM34) and similar proteins
      cd12395
      Location:288 → 360
      RRM2_RBM34; RNA recognition motif 2 in RNA-binding protein 34 (RBM34) and similar proteins

    RNA

    1. NR_027762.3 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL133418, AL732292, BM995796

    2. NR_144490.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) retains an intron in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK292362, AL133418, AL732292, BM995796, DB045266

    3. NR_144491.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an internal exon and uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK292362, AL133418, AL732292, BM995796, DB045266

    4. NR_144492.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) retains an intron in the 5' region and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK292362, AL133418, AL732292, BM995796, DB045266

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      235131183..235161250 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449700.1 → XP_047305656.1  RNA-binding protein 34 isoform X2

      UniProtKB/TrEMBL
      A2A2V2

    2. XM_011544133.3 → XP_011542435.1  RNA-binding protein 34 isoform X1

      UniProtKB/TrEMBL
      A2A2V2
      Related
      ENSP00000400000.1, ENST00000447801.5
      Conserved Domains (3) summary
      COG0724
      Location:258 → 362
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12395
      Location:268 → 340
      RRM2_RBM34; RNA recognition motif 2 in RNA-binding protein 34 (RBM34) and similar proteins
      cl17169
      Location:185 → 256
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. XM_047449705.1 → XP_047305661.1  RNA-binding protein 34 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      234522898..234552956 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054335257.1 → XP_054191232.1  RNA-binding protein 34 isoform X2

      UniProtKB/TrEMBL
      A2A2V2

    2. XM_054335256.1 → XP_054191231.1  RNA-binding protein 34 isoform X1

      UniProtKB/TrEMBL
      A2A2V2

    3. XM_054335258.1 → XP_054191233.1  RNA-binding protein 34 isoform X3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001161533.1: Suppressed sequence

      Description
      NM_001161533.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42696.2 GenPept UniProtKB/Swiss-Prot:P42696

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