SCRN2 secernin 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SCRN2provided by HGNC
Official Full Name: secernin 2provided by HGNC
Primary source: HGNC:HGNC:30381
See related: Ensembl:ENSG00000141295 MIM:614966; AllianceGenome:HGNC:30381
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Ses2
Summary: Predicted to enable cysteine-type exopeptidase activity and dipeptidase activity. Predicted to be involved in proteolysis. Located in extracellular exosome. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in fat (RPKM 52.8), kidney (RPKM 36.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q21.32

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (47837692..47841273, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (48699465..48703072, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (45915058..45918639, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cysteine-type exopeptidase activity	IEA Inferred from Electronic Annotation more info
enables dipeptidase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular exosome	HDA more info	PubMed

General protein information

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Preferred Names: secernin-2

Names: epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145023.2 → NP_001138495.1 secernin-2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate in-frame segment in the 3' coding region that results in a frameshift compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

AC003665, AW452880, BC002980

Consensus CDS

CCDS45723.1

UniProtKB/TrEMBL

J3QL71

Related

ENSP00000383935.3, ENST00000407215.7

Conserved Domains (1) summary

cl00467
Location:21 → 231

Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
NM_138355.4 → NP_612364.2 secernin-2 isoform 1

See identical proteins and their annotated locations for NP_612364.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC003665, AW452880, BC010408, CN480733

Consensus CDS

CCDS11519.1

UniProtKB/Swiss-Prot

A8K3N1, B7Z8S7, E9PBV5, Q96AC3, Q96FV2, Q9BU04

UniProtKB/TrEMBL

A0A384NKK8, J3QL71

Related

ENSP00000290216.9, ENST00000290216.14

Conserved Domains (1) summary

cl00467
Location:21 → 231

Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

47837692..47841273 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017025286.2 → XP_016880775.1 secernin-2 isoform X2

UniProtKB/TrEMBL

J3QL71
XM_047437009.1 → XP_047292965.1 secernin-2 isoform X2

UniProtKB/TrEMBL

J3QL71
XM_005257776.6 → XP_005257833.1 secernin-2 isoform X1

See identical proteins and their annotated locations for XP_005257833.1

UniProtKB/Swiss-Prot

A8K3N1, B7Z8S7, E9PBV5, Q96AC3, Q96FV2, Q9BU04

UniProtKB/TrEMBL

A0A384NKK8, J3QL71

Conserved Domains (1) summary

cl00467
Location:21 → 231

Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...