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    CG10565 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40332, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10565provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037051
    Locus tag
    Dmel_CG10565
    See related
    AllianceGenome:FB:FBgn0037051
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG10565; zuo1
    Summary
    Predicted to enable Hsp70 protein binding activity and ribosome binding activity. Predicted to be involved in 'de novo' cotranslational protein folding. Predicted to be active in cytosol. Is expressed in several structures, including adult head; anal pad primordium; embryonic/larval midgut primordium; gut section; and larval muscle cell. Orthologous to human DNAJC2 (DnaJ heat shock protein family (Hsp40) member C2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10565 in Genome Data Viewer
    Location:
    78B2-78B3; 3-47 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21133250..21136353, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21126350..21129453, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene knockout Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Islet cell autoantigen 69 kDa Neighboring gene Adenylyl cyclase 78C Neighboring gene Asparagine synthetase Neighboring gene chromosome bows

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of protein quality control regulators using a Drosophila model of TPI deficiency. Hrizo SL, et al. Neurobiol Dis, 2021 May. PMID 33600953, Free PMC Article
    2. Regulatory Mechanisms of Metamorphic Neuronal Remodeling Revealed Through a Genome-Wide Modifier Screen in Drosophila melanogaster. Chen D, et al. Genetics, 2017 Jul. PMID 28476867, Free PMC Article
    3. Neurofibromin 1 in mushroom body neurons mediates circadian wake drive through activating cAMP-PKA signaling. Machado Almeida P, et al. Nat Commun, 2021 Oct 1. PMID 34599173, Free PMC Article
    4. The Splicing Factor SF2 Is Critical for Hyperproliferation and Survival in a TORC1-Dependent Model of Early Tumorigenesis in Drosophila. Parniewska MM, et al. Int J Mol Sci, 2020 Jun 24. PMID 32599686, Free PMC Article
    5. FACS purification and transcriptome analysis of drosophila neural stem cells reveals a role for Klumpfuss in self-renewal. Berger C, et al. Cell Rep, 2012 Aug 30. PMID 22884370, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables Hsp70 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' cotranslational protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 'de novo' cotranslational protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translational fidelity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10565-PA
    CG10565-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21133250..21136353 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259927.1 → NP_001246856.1  uncharacterized protein Dmel_CG10565, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246856.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VP77
      Conserved Domains (6) summary
      smart00717
      Location:584 → 633
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      COG2214
      Location:76 → 282
      CbpA; Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription]
      cd00167
      Location:585 → 632
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam00226
      Location:76 → 145
      DnaJ; DnaJ domain
      pfam16717
      Location:332 → 401
      RAC_head; Ribosome-associated complex head domain
      cl23720
      Location:268 → 344
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    2. NM_141027.4 → NP_649284.1  uncharacterized protein Dmel_CG10565, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649284.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VP77
      Related
      FBpp0077979
      Conserved Domains (6) summary
      smart00717
      Location:584 → 633
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      COG2214
      Location:76 → 282
      CbpA; Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription]
      cd00167
      Location:585 → 632
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam00226
      Location:76 → 145
      DnaJ; DnaJ domain
      pfam16717
      Location:332 → 401
      RAC_head; Ribosome-associated complex head domain
      cl23720
      Location:268 → 344
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VP77 Q9VP77

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