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    Rai1 Rat1 Interacting Protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 2768882, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rai1provided by FlyBase
    Official Full Name
    Rat1 Interacting Protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0030793
    Locus tag
    Dmel_CG9125
    See related
    AllianceGenome:FB:FBgn0030793
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32566; CG9125; Dmel\CG9125; dRai1
    Summary
    Enables 5'-3' RNA exonuclease activity and mRNA 5'-diphosphatase activity. Predicted to be involved in NAD-cap decapping and nuclear-transcribed mRNA catabolic process. Predicted to be active in cytosol and nucleus. Is expressed in spermatozoon. Orthologous to human DXO (decapping exoribonuclease). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rai1 in Genome Data Viewer
    Location:
    15A9-15A9; 1-55 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16801929..16803344, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16695962..16697377, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene SIN3-associated polypeptide 30 Neighboring gene Rrp45 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44053 Neighboring gene pickpocket 28

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cutoff Suppresses RNA Polymerase II Termination to Ensure Expression of piRNA Precursors. Chen YA, et al. Mol Cell, 2016 Jul 7. PMID 27292797, Free PMC Article
    2. Splicing-independent loading of TREX on nascent RNA is required for efficient expression of dual-strand piRNA clusters in Drosophila. Hur JK, et al. Genes Dev, 2016 Apr 1. PMID 27036967, Free PMC Article
    3. Biogenesis of RNase P RNA from an intron requires co-assembly with cognate protein subunits. Palsule G, et al. Nucleic Acids Res, 2019 Sep 19. PMID 31287870, Free PMC Article
    4. Wolbachia and Virus Alter the Host Transcriptome at the Interface of Nucleotide Metabolism Pathways. Lindsey ARI, et al. mBio, 2021 Feb 9. PMID 33563832, Free PMC Article
    5. In vivo profiling of the Zucchini proximal proteome in the Drosophila ovary. Nguyen TTM, et al. Development, 2023 Feb 15. PMID 36762624

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 5'-3' RNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA 5'-diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 5'-diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NAD-cap decapping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Rat1 interacting protein 1
    Names
    CG9125-PA
    Rai1-PA
    NP_996492.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16801929..16803344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206769.3 → NP_996492.1  Rat1 interacting protein 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996492.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VXA8
      UniProtKB/TrEMBL
      B4F5G7, B4F5G8
      Conserved Domains (1) summary
      pfam08652
      Location:224 → 296
      RAI1; RAI1 like PD-(D/E)XK nuclease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VXA8.1 Q9VXA8

    Gene LinkOut

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