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    Agpat4 1-Acylglycerol-3-phosphate O-acyltransferase 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39819, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Agpat4provided by FlyBase
    Official Full Name
    1-Acylglycerol-3-phosphate O-acyltransferase 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0036622
    Locus tag
    Dmel_CG4753
    See related
    AllianceGenome:FB:FBgn0036622
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AGPAT; AGPAT4; CG4753; DmAGPAT3-5; Dmel\CG4753
    Summary
    Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity. Predicted to be active in endomembrane system. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; and gut section. Orthologous to human AGPAT3 (1-acylglycerol-3-phosphate O-acyltransferase 3) and AGPAT4 (1-acylglycerol-3-phosphate O-acyltransferase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Agpat4 in Genome Data Viewer
    Location:
    72E4-72E4; 3-44 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16378974..16381570, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16372074..16374670, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene roquin Neighboring gene 1-Acylglycerol-3-phosphate O-acyltransferase 3 Neighboring gene RING-associated factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparison of cardiolipins from Drosophila strains with mutations in putative remodeling enzymes. Schlame M, et al. Chem Phys Lipids, 2012 Jul. PMID 22465155
    2. Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. Wilfling F, et al. Dev Cell, 2013 Feb 25. PMID 23415954, Free PMC Article
    3. Antioxidant Role for Lipid Droplets in a Stem Cell Niche of Drosophila. Bailey AP, et al. Cell, 2015 Oct 8. PMID 26451484, Free PMC Article
    4. Diverse roles of phosphatidate phosphatases in insect development and metabolism. Lehmann M. Insect Biochem Mol Biol, 2021 Jun. PMID 32931938, Free PMC Article
    5. Thematic review series: Lipid droplet synthesis and metabolism: from yeast to man. Lipid droplet-based storage fat metabolism in Drosophila. Kühnlein RP. J Lipid Res, 2012 Aug. PMID 22566574, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    1-Acylglycerol-3-phosphate O-acyltransferase 4
    Names
    Agpat4-PA
    Agpat4-PB
    Agpat4-PC
    CG4753-PA
    CG4753-PB
    CG4753-PC
    NP_001261942.1
    NP_648887.1
    NP_730158.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16378974..16381570 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140630.3 → NP_648887.1  1-Acylglycerol-3-phosphate O-acyltransferase 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648887.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VV49
      Related
      FBpp0075179
      Conserved Domains (3) summary
      cd07990
      Location:58 → 255
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      PLN02380
      Location:12 → 366
      PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
      pfam16076
      Location:243 → 320
      Acyltransf_C; Acyltransferase C-terminus

    2. NM_001275013.1 → NP_001261942.1  1-Acylglycerol-3-phosphate O-acyltransferase 4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261942.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VV49
      Conserved Domains (3) summary
      cd07990
      Location:58 → 255
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      PLN02380
      Location:12 → 366
      PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
      pfam16076
      Location:243 → 320
      Acyltransf_C; Acyltransferase C-terminus

    3. NM_168660.2 → NP_730158.1  1-Acylglycerol-3-phosphate O-acyltransferase 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730158.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VV49
      Related
      FBpp0075180
      Conserved Domains (3) summary
      cd07990
      Location:58 → 255
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      PLN02380
      Location:12 → 366
      PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
      pfam16076
      Location:243 → 320
      Acyltransf_C; Acyltransferase C-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VV49 Q9VV49

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