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    Drep4 DNA fragmentation factor-related protein 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34734, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Drep4provided by FlyBase
    Official Full Name
    DNA fragmentation factor-related protein 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0028406
    Locus tag
    Dmel_CG9414
    See related
    AllianceGenome:FB:FBgn0028406
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CAD; CG9414; dCAD; Dmel\CG9414; Drep-4; DREP-4; drep4; DREP4; Rep4
    Summary
    Enables DNA endonuclease activity and nucleosome binding activity. Involved in apoptotic DNA fragmentation. Predicted to be located in cytoplasm and nucleus. Orthologous to human DFFB (DNA fragmentation factor subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Drep4 in Genome Data Viewer
    Location:
    34B4-34B4; 2-48 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13283912..13286462, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13283912..13286462, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44083 Neighboring gene antisense RNA:CR44972 Neighboring gene UV-resistance associated gene Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Filament-like DREP4 CIDE domain: characterization and preliminary X-ray crystallographic studies. Park HH. Acta Crystallogr F Struct Biol Commun, 2017 Aug 1. PMID 28777092, Free PMC Article
    2. Crystal structure and mutation analysis revealed that DREP2 CIDE forms a filament-like structure with features differing from those of DREP4 CIDE. Ha HJ, et al. Sci Rep, 2018 Dec 13. PMID 30546036, Free PMC Article
    3. CIDE domains form functionally important higher-order assemblies for DNA fragmentation. Choi JY, et al. Proc Natl Acad Sci U S A, 2017 Jul 11. PMID 28652364, Free PMC Article
    4. A putative role of Drep1 in apoptotic DNA fragmentation system in fly is mediated by direct interaction with Drep2 and Drep4. Park OK, et al. Apoptosis, 2013 Apr. PMID 23417746
    5. Genes with homology to DFF/CIDEs found in Drosophila melanogaster. Inohara N, et al. Cell Death Differ, 1999 Sep. PMID 10627165

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Characterization and preliminary X-ray crystallographic studies of filament-like DREP4 CIDE domain have been reported.
      Title: Filament-like DREP4 CIDE domain: characterization and preliminary X-ray crystallographic studies.
    2. study found that the interaction of Drep2 and Drep4 to Drep1 was not competitive indicating that Drep2 and Drep4 bind different place of Drep1
      Title: A putative role of Drep1 in apoptotic DNA fragmentation system in fly is mediated by direct interaction with Drep2 and Drep4.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA nuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleosome binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic DNA fragmentation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apoptotic DNA fragmentation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in apoptotic DNA fragmentation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic DNA fragmentation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA fragmentation factor-related protein 4
    Names
    CG9414-PA
    Caspase-activated DNase
    Drep4-PA
    Rep4
    NP_609631.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13283912..13286462 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135787.4 → NP_609631.1  DNA fragmentation factor-related protein 4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609631.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NDR2, Q9V3H0
      Related
      FBpp0080057
      Conserved Domains (2) summary
      cd01615
      Location:46 → 121
      CIDE_N; CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with ...
      pfam09230
      Location:151 → 435
      DFF40; DNA fragmentation factor 40 kDa
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NDR2 Q9NDR2
    Q9V3H0 Q9V3H0

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