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    Uggt UDP-glucose-glycoprotein glucosyltransferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40055, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Uggtprovided by FlyBase
    Official Full Name
    UDP-glucose-glycoprotein glucosyltransferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0014075
    Locus tag
    Dmel_CG6850
    See related
    AllianceGenome:FB:FBgn0014075
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0172774.73; anon-WO0172774.75; CG6850; Dmel\CG6850; DmUGGT; DUGT; GT; UGGT; ugt; Ugt; UGT
    Summary
    Enables UDP-glucose:glycoprotein glucosyltransferase activity. Involved in protein glycosylation. Located in nuclear envelope and rough endoplasmic reticulum. Is expressed in adult head; oocyte; and organism. Orthologous to human UGGT1 (UDP-glucose glycoprotein glucosyltransferase 1) and UGGT2 (UDP-glucose glycoprotein glucosyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Uggt in Genome Data Viewer
    Location:
    75E3-75E3; 3-45 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18872747..18878245)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18865847..18871345)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Glutaredoxin 1 Neighboring gene Biogenesis of lysosome-related organelles complex 1, subunit 3 Neighboring gene Rad9 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ninjurin B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila UDP-glucose:glycoprotein glucosyltransferase: sequence and characterization of an enzyme that distinguishes between denatured and native proteins. Parker CG, et al. EMBO J, 1995 Apr 3. PMID 7729408, Free PMC Article
    2. Single-particle electron microscopy structure of UDP-glucose:glycoprotein glucosyltransferase suggests a selectivity mechanism for misfolded proteins. Calles-Garcia D, et al. J Biol Chem, 2017 Jul 7. PMID 28490633, Free PMC Article
    3. Essential glycan-dependent interactions optimize MHC class I peptide loading. Wearsch PA, et al. Proc Natl Acad Sci U S A, 2011 Mar 22. PMID 21383180, Free PMC Article
    4. Biophysical properties of UDP-glucose:glycoprotein glucosyltransferase, a folding sensor enzyme in the ER, delineated by synthetic probes. Sakono M, et al. Biochem Biophys Res Commun, 2012 Oct 5. PMID 22960071
    5. Immunolocalization of UDP-glucose:glycoprotein glucosyltransferase indicates involvement of pre-Golgi intermediates in protein quality control. Zuber C, et al. Proc Natl Acad Sci U S A, 2001 Sep 11. PMID 11535823, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables UDP-glucose:glycoprotein glucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-glucose:glycoprotein glucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-glucose:glycoprotein glucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in rough endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UDP-glucose-glycoprotein glucosyltransferase
    Names
    CG6850-PA
    UDP-glucose:glycoprotein glucosyltransferase
    Uggt-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      18872747..18878245
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079427.3 → NP_524151.2  UDP-glucose-glycoprotein glucosyltransferase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524151.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5RIN4, Q09332, Q95U28, Q9VVT7
      Related
      FBpp0074831
      Conserved Domains (3) summary
      cd06432
      Location:1240 → 1487
      GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
      COG1442
      Location:1238 → 1456
      RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]
      pfam06427
      Location:29 → 1196
      UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09332.2 Q09332

    Gene LinkOut

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