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    RhoBTB Rho-related BTB domain containing [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40249, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RhoBTBprovided by FlyBase
    Official Full Name
    Rho-related BTB domain containingprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036980
    Locus tag
    Dmel_CG5701
    See related
    AllianceGenome:FB:FBgn0036980
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    28574635; CG5701; Dmel\CG5701; RhoGTPase; RhoX
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in melanotic encapsulation of foreign target. Predicted to be active in plasma membrane. Is expressed in several structures, including central brain primordium; dorsal epidermis primordium; embryonic dorsal epidermis; extraembryonic structure; and ganglia. Used to study developmental and epileptic encephalopathy 64. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 64. Orthologous to human RHOBTB1 (Rho related BTB domain containing 1) and RHOBTB2 (Rho related BTB domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RhoBTB in Genome Data Viewer
    Location:
    77B6-77B9; 3-47 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20376242..20382398)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20369342..20375498)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene inturned Neighboring gene uncharacterized protein Neighboring gene Insulin degrading metalloproteinase Neighboring gene uncharacterized protein Neighboring gene fumble Neighboring gene antisense RNA:CR43944

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RhoBTB Proteins Regulate the Hippo Pathway by Antagonizing Ubiquitination of LKB1. Nguyen TH, et al. G3 (Bethesda), 2020 Apr 9. PMID 32111652, Free PMC Article
    2. Missense Variants in RHOBTB2 Cause a Developmental and Epileptic Encephalopathy in Humans, and Altered Levels Cause Neurological Defects in Drosophila. Straub J, et al. Am J Hum Genet, 2018 Jan 4. PMID 29276004, Free PMC Article
    3. Rho GTPases and cell migration. Ridley AJ. J Cell Sci, 2001 Aug. PMID 11683406
    4. Novel guanine nucleotide exchange factor GEFmeso of Drosophila melanogaster interacts with Ral and Rho GTPase Cdc42. Blanke S, et al. FASEB J, 2006 Apr. PMID 16581976
    5. Conundrum, an ARHGAP18 orthologue, regulates RhoA and proliferation through interactions with Moesin. Neisch AL, et al. Mol Biol Cell, 2013 May. PMID 23468526, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cortical cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in melanotic encapsulation of foreign target IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rho-related BTB domain containing
    Names
    CG5701-PA
    CG5701-PB
    CG5701-PC
    RhoBTB-PA
    RhoBTB-PB
    RhoBTB-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20376242..20382398
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140959.2 → NP_649216.2  Rho-related BTB domain containing, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649216.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KJ62, Q961B5, Q9VPG7
      Related
      FBpp0077843
      Conserved Domains (5) summary
      cd01873
      Location:12 → 210
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      smart00174
      Location:16 → 211
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      smart00225
      Location:485 → 582
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:481 → 575
      BTB; BTB/POZ domain
      cl02518
      Location:392 → 446
      BTB; BTB/POZ domain

    2. NM_001275178.1 → NP_001262107.1  Rho-related BTB domain containing, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262107.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PG08, Q7KJ62
      Conserved Domains (5) summary
      cd01873
      Location:12 → 210
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      smart00174
      Location:16 → 211
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      smart00225
      Location:485 → 582
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:481 → 575
      BTB; BTB/POZ domain
      cl02518
      Location:392 → 446
      BTB; BTB/POZ domain

    3. NM_001275179.1 → NP_001262108.1  Rho-related BTB domain containing, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262108.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PIB5, Q7KJ62
      Conserved Domains (5) summary
      cd01873
      Location:12 → 210
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      smart00174
      Location:16 → 211
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      smart00225
      Location:485 → 582
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:481 → 575
      BTB; BTB/POZ domain
      cl02518
      Location:392 → 446
      BTB; BTB/POZ domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PG08 M9PG08
    M9PIB5 M9PIB5
    Q7KJ62 Q7KJ62
    Q9VPG7 Q9VPG7

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