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    CG4998 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39808, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4998provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036612
    Locus tag
    Dmel_CG4998
    See related
    AllianceGenome:FB:FBgn0036612
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg4998; cSPH66; Dmel\CG4998; SPH66
    Summary
    Predicted to be involved in proteolysis. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4998 in Genome Data Viewer
    Location:
    72E1-72E1; 3-44 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16339003..16345241)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16332103..16338341)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene retinin Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45893 Neighboring gene uncharacterized protein Neighboring gene Golgin 104 Neighboring gene mitochondrial ribosomal protein S34

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of cis-regulatory modules encoding temporal dynamics during development. Potier D, et al. BMC Genomics, 2014 Jun 27. PMID 24972496, Free PMC Article
    2. Base Editing of Somatic Cells Using CRISPR-Cas9 in Drosophila. Marr E, et al. CRISPR J, 2021 Dec. PMID 34813372, Free PMC Article
    3. Maintenance of mitochondrial integrity in midbrain dopaminergic neurons governed by a conserved developmental transcription factor. Miozzo F, et al. Nat Commun, 2022 Mar 17. PMID 35301315, Free PMC Article
    4. Development of fly tolerance to consuming a high-protein diet requires physiological, metabolic and transcriptional changes. Yurkevych IS, et al. Biogerontology, 2020 Oct. PMID 32468146
    5. Immunity-related genes and gene families in Anopheles gambiae. Christophides GK, et al. Science, 2002 Oct 4. PMID 12364793

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    NOT enables serine-type endopeptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4998-PA
    CG4998-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16339003..16345241
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001043144.2 → NP_001036609.1  uncharacterized protein Dmel_CG4998, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036609.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8E2
      Conserved Domains (2) summary
      smart00020
      Location:942 → 1177
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:942 → 1180
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_140621.2 → NP_648878.1  uncharacterized protein Dmel_CG4998, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648878.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VV38
      Related
      FBpp0075136
      Conserved Domains (2) summary
      smart00020
      Location:648 → 883
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:648 → 886
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0E8E2 Q0E8E2
    Q9VV38 Q9VV38

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