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    osi orsai [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 50459, updated on 9-Dec-2024

    Summary

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    Official Symbol
    osiprovided by FlyBase
    Official Full Name
    orsaiprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040985
    Locus tag
    Dmel_CG6115
    See related
    AllianceGenome:FB:FBgn0040985
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH16758; CG6115; Dmel\CG6115
    Summary
    Involved in negative regulation of cellular respiration. Predicted to be active in mitochondrion. Is expressed in adult head; adult heart; and organism. Orthologous to human ETFRF1 (electron transfer flavoprotein regulatory factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See osi in Genome Data Viewer
    Location:
    36B3-36B3; 2-53 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16887109..16887966, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16887109..16887966, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44392 Neighboring gene tweek Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. orsai, the Drosophila homolog of human ETFRF1, links lipid catabolism to growth control. Fernandez-Acosta M, et al. BMC Biol, 2022 Oct 21. PMID 36266680, Free PMC Article
    2. Drosophila Gut Immune Pathway Suppresses Host Development-Promoting Effects of Acetic Acid Bacteria. Lee J, et al. Mol Cells, 2023 Oct 31. PMID 37853687, Free PMC Article
    3. Ultra-deep sequencing of ribosome-associated poly-adenylated RNA in early Drosophila embryos reveals hundreds of conserved translated sORFs. Li H, et al. DNA Res, 2016 Dec. PMID 27559081, Free PMC Article
    4. Transcriptome analysis of FOXO-dependent hypoxia gene expression identifies Hipk as a regulator of low oxygen tolerance in Drosophila. Ding K, et al. G3 (Bethesda), 2022 Dec 1. PMID 36200850, Free PMC Article
    5. In vivo proximity biotin ligation identifies the interactome of Egalitarian, a Dynein cargo adaptor. Baker FC, et al. Development, 2021 Nov 15. PMID 35020877, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in negative regulation of cellular respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in respiratory electron transport chain IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in respiratory electron transport chain IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in respiratory electron transport chain ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    orsai
    Names
    CG6115-PA
    CG6115-PB
    osi-PA
    osi-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16887109..16887966 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299072.1 → NP_001286001.1  orsai, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286001.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJG4
      Conserved Domains (1) summary
      cd20265
      Location:5 → 80
      Complex1_LYR_ETFRF1_LYRM5; LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins

    2. NM_144321.3 → NP_652578.1  orsai, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652578.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJG4
      Related
      FBpp0080512
      Conserved Domains (1) summary
      cd20265
      Location:5 → 80
      Complex1_LYR_ETFRF1_LYRM5; LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJG4 Q9VJG4

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