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    Etl1 Etl1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34311, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Etl1provided by FlyBase
    Official Full Name
    Etl1provided by FlyBase
    Primary source
    FLYBASE:FBgn0032157
    Locus tag
    Dmel_CG5899
    See related
    AllianceGenome:FB:FBgn0032157
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5899; Dmel\CG5899; ETL1; SMARCAD1
    Summary
    Predicted to enable DNA binding activity; chromatin binding activity; and nucleosome array spacer activity. Involved in defense response to Gram-negative bacterium and positive regulation of innate immune response. Located in nucleus. Is expressed in several structures, including central brain primordium; embryonic central brain neurons; embryonic/larval midgut primordium; foregut anlage in statu nascendi; and ganglia. Human ortholog(s) of this gene implicated in BASAN syndrome and adermatoglyphia. Orthologous to human SMARCAD1 (SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Etl1 in Genome Data Viewer
    Location:
    30E1-30E4; 2-37 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9908830..9912608, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9908830..9912608, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Mucin 30E Neighboring gene uncharacterized protein Neighboring gene Splicing regulatory protein 54 Neighboring gene yippee interacting protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An integrated, directed mass spectrometric approach for in-depth characterization of complex peptide mixtures. Schmidt A, et al. Mol Cell Proteomics, 2008 Nov. PMID 18511481, Free PMC Article
    2. Transcriptional memory of dFOXO activation in youth curtails later-life mortality through chromatin remodeling and Xbp1. Martínez Corrales G, et al. Nat Aging, 2022 Dec. PMID 37118537, Free PMC Article
    3. SMARCAD1 is an ATP-dependent stimulator of nucleosomal H2A acetylation via CBP, resulting in transcriptional regulation. Doiguchi M, et al. Sci Rep, 2016 Feb 18. PMID 26888216, Free PMC Article
    4. An RNAi-Based Candidate Screen for Modifiers of the CHD1 Chromatin Remodeler and Assembly Factor in Drosophila melanogaster. Kim S, et al. G3 (Bethesda), 2015 Nov 23. PMID 26596648, Free PMC Article
    5. Flexibility in a gene network affecting a simple behavior in Drosophila melanogaster. van Swinderen B, et al. Genetics, 2005 Apr. PMID 15687281, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleosome array spacer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA double-strand break processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to Gram-negative bacterium HMP PubMed 
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of innate immune response HMP PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Etl1
    Names
    CG5899-PA
    Etl1 homologue
    Etl1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9908830..9912608 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135476.4 → NP_609320.2  Etl1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609320.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q2PDU7, Q95ST4, Q9VL72
      Related
      FBpp0079496
      Conserved Domains (2) summary
      PLN03142
      Location:271 → 815
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      cl39090
      Location:192 → 229
      ComEA; DNA uptake protein ComE and related DNA-binding proteins [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VL72.1 Q9VL72

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