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    Crtc CREB-regulated transcription coactivator [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39970, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Crtcprovided by FlyBase
    Official Full Name
    CREB-regulated transcription coactivatorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036746
    Locus tag
    Dmel_CG6064
    See related
    AllianceGenome:FB:FBgn0036746
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg6064; CG6064; crtc; CRTC; Dmel\CG6064; dTORC; dTORC2; mTORC; mTORC1; MTORC1; ORE-12; Tor-C2; TOR-C2; TORC; TORC1; TORC2
    Summary
    Enables transcription coactivator activity. Involved in several processes, including cellular response to cAMP; positive regulation of DNA-templated transcription; and response to oxidative stress. Located in cytosol and nucleus. Is expressed in organism. Orthologous to several human genes including CRTC1 (CREB regulated transcription coactivator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Crtc in Genome Data Viewer
    Location:
    74E4-74E5; 3-45 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17659818..17669234, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17652918..17662334, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Nedd4 family interacting protein Neighboring gene Keren Neighboring gene uncharacterized protein Neighboring gene small non-coding RNA 641 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45976 Neighboring gene Ccn

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins. Bittinger MA, et al. Curr Biol, 2004 Dec 14. PMID 15589160
    2. Regulation of energy stores and feeding by neuronal and peripheral CREB activity in Drosophila. Iijima K, et al. PLoS One, 2009 Dec 30. PMID 20041126, Free PMC Article
    3. TORC2: a novel target for treating age-associated memory impairment. Johnson JL, et al. Sci Rep, 2015 Oct 22. PMID 26489398, Free PMC Article
    4. The CRTC-CREB axis functions as a transcriptional sensor to protect against proteotoxic stress in Drosophila. Yin Y, et al. Cell Death Dis, 2022 Aug 6. PMID 35933423, Free PMC Article
    5. Drosophila salt-inducible kinase (SIK) regulates starvation resistance through cAMP-response element-binding protein (CREB)-regulated transcription coactivator (CRTC). Choi S, et al. J Biol Chem, 2011 Jan 28. PMID 21127058, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TORC1 regulation of dendrite regrowth after pruning is linked to actin and exocytosis.
      Title: TORC1 regulation of dendrite regrowth after pruning is linked to actin and exocytosis.
    2. the article describes a novel mechanism in Drosophila by which TORC1 regulates RNA processing of Atg transcripts and alters ATG protein levels and activities via the cleavage and polyadenylation (CPA) complex.
      Title: The TORC1-Regulated CPA Complex Rewires an RNA Processing Network to Drive Autophagy and Metabolic Reprogramming.
    3. data suggest that CRTC is a novel co-activator for the CLK/CYC-activated tim transcription to coordinate molecular rhythms with circadian behaviors over a 24-hour time-scale.
      Title: CRTC Potentiates Light-independent timeless Transcription to Sustain Circadian Rhythms in Drosophila.
    4. Upon TORC1 inhibition, REPTOR becomes dephosphorylated in a PP2A-dependent manner
      Title: REPTOR and REPTOR-BP Regulate Organismal Metabolism and Transcription Downstream of TORC1.
    5. fasting-dependent long-term memory uses the CREB coactivator CRTC
      Title: Fasting launches CRTC to facilitate long-term memory formation in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cAMP response element binding protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cAMP response element binding protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to cAMP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to cAMP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of CREB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CREB-regulated transcription coactivator
    Names
    CG6064-PA
    CG6064-PB
    CG6064-PC
    Crtc-PA
    Crtc-PB
    Crtc-PC
    TORC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17659818..17669234 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275068.2 → NP_001261997.1  CREB-regulated transcription coactivator, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261997.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFU2
      Conserved Domains (2) summary
      pfam12884
      Location:3 → 61
      TORC_N; Transducer of regulated CREB activity, N terminus
      pfam12886
      Location:739 → 795
      TORC_C; Transducer of regulated CREB activity, C terminus

    2. NM_001300172.1 → NP_001287101.1  CREB-regulated transcription coactivator, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287101.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVJ8
      Conserved Domains (2) summary
      pfam12884
      Location:3 → 61
      TORC_N; Transducer of regulated CREB activity, N terminus
      pfam12886
      Location:739 → 795
      TORC_C; Transducer of regulated CREB activity, C terminus

    3. NM_140744.3 → NP_649001.1  CREB-regulated transcription coactivator, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649001.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVJ8
      Related
      FBpp0074960
      Conserved Domains (2) summary
      pfam12884
      Location:3 → 61
      TORC_N; Transducer of regulated CREB activity, N terminus
      pfam12886
      Location:739 → 795
      TORC_C; Transducer of regulated CREB activity, C terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PFU2 M9PFU2
    Q9VVJ8 Q9VVJ8

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