qkr58E-2 quaking related 58E-2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: qkr58E-2provided by FlyBase
Official Full Name: quaking related 58E-2provided by FlyBase
Primary source: FLYBASE:FBgn0022985
Locus tag: Dmel_CG5821
See related: AllianceGenome:FB:FBgn0022985
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5821; Dmel\CG5821; qkr58e-2; qrk58E-2
Summary: Predicted to enable mRNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be active in nucleus. Is expressed in adult head; germline cell; and organism. Orthologous to human KHDRBS1 (KH RNA binding domain containing, signal transduction associated 1) and KHDRBS2 (KH RNA binding domain containing, signal transduction associated 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 58D8-58E1; 2-99 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (22415560..22419001)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (18303065..18306506)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: quaking related 58E-2

Names: CG5821-PA; CG5821-PB; CG5821-PC; qkr58E-2-PA; qkr58E-2-PB; qkr58E-2-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

22415560..22419001

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001299795.1 → NP_001286724.1 quaking related 58E-2, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286724.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9W254

Conserved Domains (1) summary

cd02395
Location:129 → 244

SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
NM_001299796.1 → NP_001286725.1 quaking related 58E-2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286725.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9W254

Conserved Domains (1) summary

cd02395
Location:129 → 244

SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
NM_079086.3 → NP_523810.2 quaking related 58E-2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523810.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9W254

Related

FBpp0071739

Conserved Domains (1) summary

cd02395
Location:129 → 244

SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...