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    Surf1 Surfeit 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44498, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Surf1provided by FlyBase
    Official Full Name
    Surfeit 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0029117
    Locus tag
    Dmel_CG9943
    See related
    AllianceGenome:FB:FBgn0029117
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH23574; CG9943; Dmel\CG9943; SUR1
    Summary
    Involved in several processes, including mitochondrial respirasome assembly; phototaxis; and visual behavior. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in adult head. Used to study Leigh disease and mitochondrial complex IV deficiency nuclear type 1. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4K; Leigh disease; and mitochondrial complex IV deficiency nuclear type 1. Orthologous to human SURF1 (SURF1 cytochrome c oxidase assembly factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Surf1 in Genome Data Viewer
    Location:
    65D4-65D4; 3-18 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6958346..6959586)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6951446..6952686)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ubiquinol-cytochrome c reductase complex assembly factor 1 Neighboring gene sugarless Neighboring gene uncharacterized protein Neighboring gene Mis12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Post-transcriptional silencing and functional characterization of the Drosophila melanogaster homolog of human Surf1. Zordan MA, et al. Genetics, 2006 Jan. PMID 16172499, Free PMC Article
    2. Leigh syndrome in Drosophila melanogaster: morphological and biochemical characterization of Surf1 post-transcriptional silencing. Da-Rè C, et al. J Biol Chem, 2014 Oct 17. PMID 25164807, Free PMC Article
    3. Sequence conservation from human to prokaryotes of Surf1, a protein involved in cytochrome c oxidase assembly, deficient in Leigh syndrome. Poyau A, et al. FEBS Lett, 1999 Dec 3. PMID 10622737
    4. Expression of the Ciona intestinalis alternative oxidase (AOX) in Drosophila complements defects in mitochondrial oxidative phosphorylation. Fernandez-Ayala DJ, et al. Cell Metab, 2009 May. PMID 19416715
    5. Mitochondrial retrograde signaling regulates neuronal function. Cagin U, et al. Proc Natl Acad Sci U S A, 2015 Nov 3. PMID 26489648, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in instar larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial cytochrome c oxidase assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial respirasome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phototaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in visual behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    surfeit 1
    Names
    CG9943-PA
    Surf1-PA
    surfeit locus protein 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6958346..6959586
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080019.3 → NP_524758.1  surfeit 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524758.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MSH4, Q9U4F3, Q9VRZ8
      UniProtKB/TrEMBL
      C3KGL8
      Related
      FBpp0076607
      Conserved Domains (1) summary
      cd06662
      Location:74 → 289
      SURF1; SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U4F3.1 Q9U4F3

    Gene LinkOut

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