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    Brr2 Brr2 U5 snRNP complex subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39737, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Brr2provided by FlyBase
    Official Full Name
    Brr2 U5 snRNP complex subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263599
    Locus tag
    Dmel_CG5931
    See related
    AllianceGenome:FB:FBgn0263599
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Liang-1.21; ASCC3L1; brr2; cg5931; CG5931; clone 1.21; Dmel\CG5931; l(3)72Ab
    Summary
    Predicted to enable RNA helicase activity. Involved in mRNA splicing, via spliceosome; regulation of alternative mRNA splicing, via spliceosome; and spermatogenesis. Located in nucleus. Part of small nuclear ribonucleoprotein complex. Is expressed in adult head; adult heart; organism; and spermatozoon. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 33. Orthologous to human SNRNP200 (small nuclear ribonucleoprotein U5 subunit 200). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Brr2 in Genome Data Viewer
    Location:
    72C1-72C1; 3-43 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15960836..15967872, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15953936..15960972, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene early girl Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene brahma Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila homeotic gene moira regulates expression of engrailed and HOM genes in imaginal tissues. Brizuela BJ, et al. Mech Dev, 1997 Jul. PMID 9256357
    2. Specification of Drosophila neuropeptidergic neurons by the splicing component brr2. Monedero Cobeta I, et al. PLoS Genet, 2018 Aug. PMID 30133436, Free PMC Article
    3. Spliceosome factors target timeless (tim) mRNA to control clock protein accumulation and circadian behavior in Drosophila. Shakhmantsir I, et al. Elife, 2018 Dec 5. PMID 30516472, Free PMC Article
    4. Unexpected role of the steroid-deficiency protein ecdysoneless in pre-mRNA splicing. Claudius AK, et al. PLoS Genet, 2014 Apr. PMID 24722212, Free PMC Article
    5. Major spliceosome defects cause male infertility and are associated with nonobstructive azoospermia in humans. Wu H, et al. Proc Natl Acad Sci U S A, 2016 Apr 12. PMID 27035939, Free PMC Article

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic cell cycle HMP PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ventral cord development HMP PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of precatalytic spliceosome HDA PubMed 
    part_of small nuclear ribonucleoprotein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Brr2 U5 snRNP complex subunit
    Names
    Brr2-PA
    CG5931-PA
    lethal (3) 72Ab
    NP_648818.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15960836..15967872 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140561.4 → NP_648818.3  Brr2 U5 snRNP complex subunit [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648818.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5U0X1, Q8T9I9, Q9VUV9
      Related
      FBpp0075282
      Conserved Domains (5) summary
      smart00490
      Location:773 → 859
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:1320 → 1506
      DEXDc; DEAD-like helicases superfamily
      COG1204
      Location:466 → 1241
      BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
      pfam00270
      Location:482 → 661
      DEAD; DEAD/DEAH box helicase
      pfam02889
      Location:982 → 1285
      Sec63; Sec63 Brl domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VUV9.4 Q9VUV9

    Gene LinkOut

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