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    Rh4 Rhodopsin 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39887, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rh4provided by FlyBase
    Official Full Name
    Rhodopsin 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0003250
    Locus tag
    Dmel_CG9668
    See related
    AllianceGenome:FB:FBgn0003250
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9668; Dm Rh4; DMELRH4; Dmel\CG9668; r4; Rh; rh4; RH4
    Summary
    Enables G protein-coupled photoreceptor activity. Involved in phototransduction, UV. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; photoreceptor; and photoreceptor neurons. Orthologous to human OPN4 (opsin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rh4 in Genome Data Viewer
    Location:
    73D2-73D3; 3-45 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16852527..16862517, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16845627..16855617, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Tumor susceptibility gene 101 Neighboring gene uncharacterized protein Neighboring gene Zinc finger CCHC-type containing 7 Neighboring gene kuduk Neighboring gene seven in absentia Neighboring gene uncharacterized protein Neighboring gene sina homologue Neighboring gene uncharacterized protein Neighboring gene Limpet Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A second opsin gene expressed in the ultraviolet-sensitive R7 photoreceptor cells of Drosophila melanogaster. Montell C, et al. J Neurosci, 1987 May. PMID 2952772, Free PMC Article
    2. Two types of Drosophila R7 photoreceptor cells are arranged randomly: a model for stochastic cell-fate determination. Bell ML, et al. J Comp Neurol, 2007 May 1. PMID 17335038
    3. Gene organization: nested genes take flight. Mount S, et al. Curr Biol, 1993 Jun 1. PMID 15335735
    4. Vitamin A, visual pigments, and visual receptors in Drosophila. Lee RD, et al. Microsc Res Tech, 1996 Dec 15. PMID 9016446
    5. The role of Drosophila ninaG oxidoreductase in visual pigment chromophore biogenesis. Ahmad ST, et al. J Biol Chem, 2006 Apr 7. PMID 16464863

    See all (238) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Co-expression of Rhodopsin 4 with Rhodopsin 3 in Drosophila
      Title: Iroquois complex genes induce co-expression of rhodopsins in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled photoreceptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled photoreceptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G protein-coupled photoreceptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables G protein-coupled photoreceptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables G protein-coupled photoreceptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in cellular response to light stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detection of UV TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in phototransduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phototransduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in phototransduction, UV IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phototransduction, UV NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in phototransduction, UV TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rhodopsin 4
    Names
    CG9668-PA
    Rh4-PA
    Rhodopsin4
    rhodopsin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16852527..16862517 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057353.4 → NP_476701.1  rhodopsin 4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476701.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P08255, Q9VVB3
      UniProtKB/TrEMBL
      B5RJL1, Q9TX52
      Related
      FBpp0075097
      Conserved Domains (1) summary
      cd15079
      Location:55 → 345
      7tmA_photoreceptors_insect; insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08255.2 P08255
    Q8MYV5 Q8MYV5

    Gene LinkOut

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