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    Stoml2 Stomatin like 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37807, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Stoml2provided by FlyBase
    Official Full Name
    Stomatin like 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0034936
    Locus tag
    Dmel_CG2970
    See related
    AllianceGenome:FB:FBgn0034936
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2970; Dmel\CG2970; dmSTOML2; dSLP-2; SD03319p
    Summary
    Predicted to be involved in mitochondrion organization. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut; and embryonic/larval midgut primordium. Orthologous to human STOML2 (stomatin like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Stoml2 in Genome Data Viewer
    Location:
    60A13-60A13; 2-105 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23949201..23952459)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19836724..19839982)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene G protein alpha subunit s Neighboring gene orcokinin Neighboring gene fizzy-related 2 Neighboring gene uncharacterized protein Neighboring gene thoc5 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SLP-2 interacts with Parkin in mitochondria and prevents mitochondrial dysfunction in Parkin-deficient human iPSC-derived neurons and Drosophila. Zanon A, et al. Hum Mol Genet, 2017 Jul 1. PMID 28379402, Free PMC Article
    2. Completion of mitosis requires neither fzr/rap nor fzr2, a male germline-specific Drosophila Cdh1 homolog. Jacobs H, et al. Curr Biol, 2002 Aug 20. PMID 12194827
    3. The THO complex is required for nucleolar integrity in Drosophila spermatocytes. Moon S, et al. Development, 2011 Sep. PMID 21828100
    4. DDX17 is involved in DNA damage repair and modifies FUS toxicity in an RGG-domain dependent manner. Fortuna TR, et al. Acta Neuropathol, 2021 Sep. PMID 34061233, Free PMC Article
    5. Genome-wide phenotypic RNAi screen in the Drosophila wing: global parameters. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599819, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    stomatin like 2
    Names
    CG2970-PA
    CG2970-PB
    Stoml2-PA
    Stoml2-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23949201..23952459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138009.3 → NP_611853.2  stomatin like 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611853.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T3K9, Q9W1F7
      Related
      FBpp0072054
      Conserved Domains (3) summary
      smart00244
      Location:41 → 199
      PHB; prohibitin homologues
      cd08829
      Location:80 → 188
      SPFH_paraslipin; Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
      pfam16200
      Location:266 → 326
      Band_7_C; C-terminal region of band_7

    2. NM_001274232.1 → NP_001261161.1  stomatin like 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261161.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T3K9, Q9W1F7
      Conserved Domains (3) summary
      smart00244
      Location:41 → 199
      PHB; prohibitin homologues
      cd08829
      Location:80 → 188
      SPFH_paraslipin; Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
      pfam16200
      Location:266 → 326
      Band_7_C; C-terminal region of band_7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T3K9 Q8T3K9
    Q9W1F7 Q9W1F7

    Gene LinkOut

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