HisCl1 Histamine-gated chloride channel subunit 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: HisCl1provided by FlyBase
Official Full Name: Histamine-gated chloride channel subunit 1provided by FlyBase
Primary source: FLYBASE:FBgn0037950
Locus tag: Dmel_CG14723
See related: AllianceGenome:FB:FBgn0037950
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG14723; CT34515; Dm-HCLB; Dmel\CG14723; DmHisCl1; DMHisClalpha2; HA-CI II; hclB; HisCl; HisCl-alpha2; hiscl1; hisCl1
Summary: Enables histamine-gated chloride channel activity. Involved in chloride transport and thermotaxis. Part of histamine-gated chloride channel complex. Is expressed in several structures, including adult pacemaker neurons; anterior-posterior subdivision of organism; photoreceptor; photoreceptor neurons; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in hyperekplexia 1 and syndromic X-linked intellectual disability Pilorge type. Orthologous to human GLRA1 (glycine receptor alpha 1) and GLRA2 (glycine receptor alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 86F7-86F8; 3-51 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (11787176..11789393)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (7612898..7615115)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study results show that both Ort and HisCl1 define two different pathways for circadian entrainment. Whereas Ort contributes through its expression in the interneurons of the optic lobe, HisCl1 mostly contributes through its expression in the Rh6-expressing retinal photoreceptors. The work thus reveals that Rh6-expressing neurons contribute to light-mediated entrainment as both photoreceptors and interneurons.
Title: The HisCl1 histamine receptor acts in photoreceptors to synchronize Drosophila behavioral rhythms with light-dark cycles.
The activity of HisCl1-expressing neurons is acutely and reversibly silenced by exogenous histamine.
Title: Inducible and titratable silencing of Caenorhabditis elegans neurons in vivo with histamine-gated chloride channels.
may play an essential and conserved role in insect neurophysiology
Title: Functional consequences of mutations in the Drosophila histamine receptor HCLB.
These results identify HCLB as an important in vivo target for ivermectin in Drosophila melanogaster, and demonstrate the involvement of this protein in the visual pathway.
Title: Altered ivermectin pharmacology and defective visual system in Drosophila mutants for histamine receptor HCLB.
Histamine-gated chloride channel hclB signaling via the lamina glia plays a previously unrecognized role in shaping the photoreceptor postsynaptic response on large monopolar cells.
Title: Distinct roles for two histamine receptors (hclA and hclB) at the Drosophila photoreceptor synapse.
the genes encoding for proteins involved in histamine signaling [histidine decarboxylase (hdc), histamine-gated chloride channel subunit 1 (hisCl1), ora transientless (ort)] cause abnormal temperature preferences
Title: Histamine and its receptors modulate temperature-preference behaviors in Drosophila.

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables excitatory extracellular ligand-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables histamine-gated chloride channel activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in thermotaxis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of histamine-gated chloride channel complex	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed

General protein information

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Preferred Names: Histamine-gated chloride channel subunit 1

Names: CG14723-PA; CG14723-PB; CG14723-PC; CG14723-PD; HisCl1-PA; HisCl1-PB; HisCl1-PC; HisCl1-PD; glycine receptor alpha3 subunit-like; histamine-gated chloride channel subunit 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

11787176..11789393

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_169429.4 → NP_731632.1 Histamine-gated chloride channel subunit 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731632.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8T9R9, Q9VGI0

Related

FBpp0081946

Conserved Domains (2) summary

pfam02931
Location:67 → 262

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:270 → 350

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_141859.4 → NP_650116.2 Histamine-gated chloride channel subunit 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_650116.2

Status: REVIEWED

UniProtKB/TrEMBL

B5SUY9, Q8WS32

Conserved Domains (2) summary

pfam02931
Location:67 → 262

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:270 → 350

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_001170120.2 → NP_001163591.1 Histamine-gated chloride channel subunit 1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163591.1

Status: REVIEWED

UniProtKB/TrEMBL

B5SUY9, E1JII9

Conserved Domains (2) summary

pfam02931
Location:67 → 256

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:264 → 344

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_206474.3 → NP_996196.1 Histamine-gated chloride channel subunit 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996196.1

Status: REVIEWED

UniProtKB/TrEMBL

Q95T69

Conserved Domains (1) summary

pfam02931
Location:67 → 202

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain