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    CDK2AP1 CDK2-associated protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32050, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CDK2AP1provided by FlyBase
    Official Full Name
    CDK2-associated protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0030269
    Locus tag
    Dmel_CG18292
    See related
    AllianceGenome:FB:FBgn0030269
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO03040301.144; CG18292; Dmel\CG18292; DOC1
    Summary
    Predicted to enable DNA polymerase binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including central brain primordium; embryonic hindgut; ganglia; and gonad. Orthologous to several human genes including CDK2AP1 (cyclin dependent kinase 2 associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CDK2AP1 in Genome Data Viewer
    Location:
    10A6-10A7; 1-33 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11137859..11139689)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11031892..11033722)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Signal recognition particle receptor alpha Neighboring gene Kinesin-like protein at 10A Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44054 Neighboring gene short spindle 7 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Retroactive, a membrane-anchored extracellular protein related to vertebrate snake neurotoxin-like proteins, is required for cuticle organization in the larva of Drosophila melanogaster. Moussian B, et al. Dev Dyn, 2005 Jul. PMID 15844167
    2. Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. Reddy BA, et al. Mol Cell Biol, 2010 Nov. PMID 20733004, Free PMC Article
    3. The Nucleosome Remodeling and Deacetylase Complex NuRD Is Built from Preformed Catalytically Active Sub-modules. Zhang W, et al. J Mol Biol, 2016 Jul 17. PMID 27117189, Free PMC Article
    4. RNAi experiments in D. melanogaster: solutions to the overlooked problem of off-targets shared by independent dsRNAs. Seinen E, et al. PLoS One, 2010 Oct 1. PMID 20957038, Free PMC Article
    5. Characteristics of molecular-genetic organization of intercalary heterochromatin band 10A1-2 in X chromosome of Drosophila melanogaster. Babenko VN, et al. Dokl Biochem Biophys, 2009 Jan-Feb. PMID 19341102

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA polymerase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    CDK2-associated protein 1
    Names
    CDK2AP1-PA
    CDK2AP1-PB
    CG18292-PA
    CG18292-PB
    deleted in oral cancer 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11137859..11139689
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132460.3 → NP_572688.2  CDK2-associated protein 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572688.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZ27
      Related
      FBpp0073293
      Conserved Domains (1) summary
      pfam09806
      Location:1 → 280
      CDK2AP; Cyclin-dependent kinase 2-associated protein

    2. NM_001272510.1 → NP_001259439.1  CDK2-associated protein 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259439.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEA2
      Conserved Domains (1) summary
      pfam09806
      Location:1 → 280
      CDK2AP; Cyclin-dependent kinase 2-associated protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PEA2 M9PEA2
    Q8T006 Q8T006
    Q9VZ27 Q9VZ27

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