U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Sce Sex combs extra [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43327, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Sceprovided by FlyBase
    Official Full Name
    Sex combs extraprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003330
    Locus tag
    Dmel_CG5595
    See related
    AllianceGenome:FB:FBgn0003330
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5595; Ding; Dmel\CG5595; dring; dRing; dRING; Dring; DRING; dRing1; dRING1; dRNIG; Ring; RING; Ring/Sce; RING/Sce; RING1; Rnf2; sce; SCE; Sce/dRing; See/dRing
    Summary
    Enables ubiquitin protein ligase activity. Involved in several processes, including anterior/posterior axis specification; follicle cell of egg chamber development; and regulation of gene expression. Located in chromatin; nuclear envelope; and nucleolus. Part of PRC1 complex. Is expressed in several structures, including antennal primordium; anterior endoderm anlage; ganglia; head epidermis primordium; and mesoderm. Used to study Luo-Schoch-Yamamoto syndrome and cancer. Human ortholog(s) of this gene implicated in Luo-Schoch-Yamamoto syndrome. Orthologous to several human genes including RNF2 (ring finger protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Sce in Genome Data Viewer
    Location:
    98B1-98B1; 3-94 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27680431..27682029, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23506153..23507751, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Hydroxysteroid dehydrogenase like 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Ubiquitylome study identifies increased histone 2A ubiquitylation as an evolutionarily conserved aging biomarker. Yang L, et al. Nat Commun, 2019 May 21. PMID 31113955, Free PMC Article
    2. A proposed role for the Polycomb group protein dRING in meiotic sister-chromatid cohesion. Balicky EM, et al. Chromosoma, 2004 Feb. PMID 14669021
    3. Rare deleterious de novo missense variants in Rnf2/Ring2 are associated with a neurodevelopmental disorder with unique clinical features. Luo X, et al. Hum Mol Genet, 2021 Jun 26. PMID 33864376, Free PMC Article
    4. Directed overexpression of suppressor 2 of zeste and Posterior Sex Combs results in bristle abnormalities in Drosophila melanogaster. Sharp EJ, et al. Dev Biol, 1994 Feb. PMID 8313990
    5. Coordinate redeployment of PRC1 proteins suppresses tumor formation during Drosophila development. Loubière V, et al. Nat Genet, 2016 Nov. PMID 27643538, Free PMC Article

    See all (233) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fsh physically interacts with Pc-Sce complex.Sce is required for Ci transcription
      Title: Fsh-Pc-Sce complex mediates active transcription of Cubitus interruptus (Ci).
    2. SCE, together with dRYBP, inhibits apoptosis either by epigenetically regulating Dp53 transcription or by controlling the stabilization of DP53 protein levels thus promoting its ubiquitylation for proteaosomal degradation.
      Title: Drosophila SCE/dRING E3-ligase inhibits apoptosis in a Dp53 dependent manner.
    3. Sce synergizes with the Polycomb repressive deubiquitinase complex to repress transcription at class I genes, suggesting that H2A monoubiquitylation must be appropriately balanced for their transcriptional repression.
      Title: The role of the histone H2A ubiquitinase Sce in Polycomb repression.
    4. a novel role for protein dRING; promotes the proper segregation of meiotic chromosomes
      Title: A proposed role for the Polycomb group protein dRING in meiotic sister-chromatid cohesion.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anterior/posterior axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in follicle cell of egg chamber stalk formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germarium-derived female germ-line cyst encapsulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heterochromatin formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ventral cord development HMP PubMed 
    Component Evidence Code Pubs
    part_of PRC1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of PcG protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of PcG protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in condensed chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Sex combs extra
    Names
    CG5595-PA
    SCE/dRING
    Sce-PA
    Sex comb extra
    dRING1
    ring

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27680431..27682029 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058161.4 → NP_477509.1  Sex combs extra [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477509.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18380, Q9VB08
      Related
      FBpp0084614
      Conserved Domains (2) summary
      cd00162
      Location:45 → 89
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam16207
      Location:336 → 431
      RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VB08.1 Q9VB08

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous