me31B maternal expression at 31B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: me31Bprovided by FlyBase
Official Full Name: maternal expression at 31Bprovided by FlyBase
Primary source: FLYBASE:FBgn0004419
Locus tag: Dmel_CG4916
See related: AllianceGenome:FB:FBgn0004419
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4916; DDX6; Dhh1p/Me31b; Dmel\CG4916; DmRH3; l(2)k06607; Mat31B; me31b; Me31b; Me31B; ME31B
Summary: Enables RNA binding activity and mRNA regulatory element binding translation repressor activity. Involved in several processes, including P-body assembly; habituation; and regulation of gene expression. Located in several cellular components, including cytoplasmic ribonucleoprotein granule; neuronal cell body; and sensory dendrite. Colocalizes with endoplasmic reticulum exit site. Is expressed in several structures, including adult brain; adult brain cell body rind; adult head; germline cell; and intrinsic neurons. Orthologous to human DDX6 (DEAD-box helicase 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 31B1-31B1; 2-40 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (10239341..10242172)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (10239341..10242172)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutational analysis of the functional motifs of the DEAD-box RNA helicase Me31B/DDX6 in Drosophila germline development.
Title: Mutational analysis of the functional motifs of the DEAD-box RNA helicase Me31B/DDX6 in Drosophila germline development.
Drosophila Me31B is a Dual eIF4E-Interacting Protein.
Title: Drosophila Me31B is a Dual eIF4E-Interacting Protein.
me31B regulates stem cell homeostasis by preventing excess dedifferentiation in the Drosophila male germline.
Title: me31B regulates stem cell homeostasis by preventing excess dedifferentiation in the Drosophila male germline.
Comparative Proteomics Reveal Me31B's Interactome Dynamics, Expression Regulation, and Assembly Mechanism into Germ Granules during Drosophila Germline Development.
Title: Comparative Proteomics Reveal Me31B's Interactome Dynamics, Expression Regulation, and Assembly Mechanism into Germ Granules during Drosophila Germline Development.
Me31B and Wdr62 function as two novel modulators of Notch signaling activity.
Title: A genetic mosaic screen identifies genes modulating Notch signaling in Drosophila.
The authors show that the RNA-binding protein, ME31B, binds to and represses the expression of thousands of maternal mRNAs during the Drosophila maternal-to-zygotic transition.
Title: ME31B globally represses maternal mRNAs by two distinct mechanisms during the Drosophila maternal-to-zygotic transition.
study supports the role of Me31B in RNA regulation and suggests its novel roles in germ granule assembly and function.
Title: An in vivo proteomic analysis of the Me31B interactome in Drosophila germ granules.
Me31B role in the translational repression of the Drosophila Nanos mRNA
Title: Translational repression of the Drosophila nanos mRNA involves the RNA helicase Belle and RNA coating by Me31B and Trailer hitch.
LSM12 and ME31B/DDX6 define distinct modes of posttranscriptional regulation by ATAXIN-2 protein complex in drosophila circadian pacemaker neurons.
Title: LSM12 and ME31B/DDX6 Define Distinct Modes of Posttranscriptional Regulation by ATAXIN-2 Protein Complex in Drosophila Circadian Pacemaker Neurons.
PAPI, a novel TUDOR-domain protein, complexes with AGO3, ME31B and TRAL in the nuage to silence transposition.
Title: PAPI, a novel TUDOR-domain protein, complexes with AGO3, ME31B and TRAL in the nuage to silence transposition.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA regulatory element binding translation repressor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in P-body assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in P-body assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA	IGI Inferred from Genetic Interaction more info	PubMed
involved_in deadenylation-independent decapping of nuclear-transcribed mRNA	IDA Inferred from Direct Assay more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in habituation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in miRNA-mediated gene silencing by inhibition of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in miRNA-mediated gene silencing by inhibition of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in miRNA-mediated post-transcriptional gene silencing	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cytoplasmic translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in pole cell formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of mRNA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of post-transcriptional gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron projection arborization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stress granule assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in P granule	IDA Inferred from Direct Assay more info	PubMed
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic ribonucleoprotein granule	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with endoplasmic reticulum exit site	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal ribonucleoprotein granule	IDA Inferred from Direct Assay more info	PubMed
located_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in sensory dendrite	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: maternal expression at 31B

Names: CG4916-PA; CG4916-PB; me31B-PA; me31B-PB

NP_523533.2

EC 3.6.4.13

NP_723539.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

10239341..10242172

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078809.4 → NP_523533.2 maternal expression at 31B, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523533.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P23128, Q8IPC9, Q961D2, Q9VL17

Related

FBpp0079565

Conserved Domains (3) summary

PTZ00424
Location:60 → 422

PTZ00424; helicase 45; Provisional

cd00079
Location:270 → 398

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cd00268
Location:60 → 260

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
NM_164898.2 → NP_723539.1 maternal expression at 31B, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723539.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P23128

Related

FBpp0079566

Conserved Domains (1) summary

COG0513
Location:4 → 388

SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]