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    glec gliolectin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42571, updated on 9-Dec-2024

    Summary

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    Official Symbol
    glecprovided by FlyBase
    Official Full Name
    gliolectinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015229
    Locus tag
    Dmel_CG6575
    See related
    AllianceGenome:FB:FBgn0015229
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6575; Dmel\CG6575
    Summary
    Enables carbohydrate binding activity. Involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules and nervous system development. Located in plasma membrane. Is expressed in several structures, including adult brain cell body rind; dorsal-ventral compartment boundary of the wing disc; ectoderm; mesectoderm anlage; and midline primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See glec in Genome Data Viewer
    Location:
    93F14-93F14; 3-73 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21850694..21856266, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17676416..17681988, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44087 Neighboring gene Gustatory receptor 93c Neighboring gene Gustatory receptor 93d Neighboring gene long non-coding RNA:CR45644 Neighboring gene long non-coding RNA:CR45645

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gliolectin is a novel carbohydrate-binding protein expressed by a subset of glia in the embryonic Drosophila nervous system. Tiemeyer M, et al. Development, 1996 Mar. PMID 8631270
    2. Gliolectin positively regulates Notch signalling during wing-vein specification in Drosophila. Prasad N, et al. Int J Dev Biol, 2015. PMID 26505251
    3. Gliolectin-mediated carbohydrate binding at the Drosophila midline ensures the fidelity of axon pathfinding. Sharrow M, et al. Development, 2001 Nov. PMID 11714683
    4. Innate recognition systems in insect immunity and development: new approaches in Drosophila. Franc NC, et al. Microbes Infect, 2000 Mar. PMID 10758400
    5. Time-lapse imaging reveals stereotypical patterns of Drosophila midline glial migration. Wheeler SR, et al. Dev Biol, 2012 Jan 15. PMID 22061481, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that gliolectin is a positive regulator of Notch receptor signalling during wing development.
      Title: Gliolectin positively regulates Notch signalling during wing-vein specification in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carbohydrate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carbohydrate binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleoplasm HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gliolectin
    Names
    CG6575-PA
    glec-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      21850694..21856266 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079719.3 → NP_524443.2  gliolectin [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524443.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A9UNC5, Q24166, Q8T0Q9, Q9VD73
      UniProtKB/TrEMBL
      D3DME2
      Related
      FBpp0083555
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VD73.1 Q9VD73

    Gene LinkOut

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