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    ValRS-m Valyl-tRNA synthetase, mitochondrial [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39023, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ValRS-mprovided by FlyBase
    Official Full Name
    Valyl-tRNA synthetase, mitochondrialprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035942
    Locus tag
    Dmel_CG5660
    See related
    AllianceGenome:FB:FBgn0035942
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5660; Dmel\CG5660
    Summary
    Predicted to enable valine-tRNA ligase activity. Predicted to be involved in valyl-tRNA aminoacylation. Predicted to be located in mitochondrion. Predicted to be active in cytosol. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; gastric caecum; gut section; and larval muscle system. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 20. Orthologous to human VARS2 (valyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ValRS-m in Genome Data Viewer
    Location:
    66E5-66E5; 3-27 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8961274..8964769, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8954374..8957869, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L12 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cytoplasmic and mitochondrial protein translation in axonal and dendritic terminal arborization. Chihara T, et al. Nat Neurosci, 2007 Jul. PMID 17529987
    2. Deficiency of ValRS-m Causes Male Infertility in Drosophila melanogaster. Duan X, et al. Int J Mol Sci, 2024 Jul 8. PMID 39000597, Free PMC Article
    3. The aminoacyl-tRNA synthetases of Drosophila melanogaster. Lu J, et al. Fly (Austin), 2015. PMID 26761199, Free PMC Article
    4. Towards comprehensive annotation of Drosophila melanogaster enzymes in FlyBase. Garapati PV, et al. Database (Oxford), 2019 Jan 1. PMID 30689844, Free PMC Article
    5. A functional genomics screen identifying blood cell development genes in Drosophila by undergraduates participating in a course-based research experience. Evans CJ, et al. G3 (Bethesda), 2021 Jan 18. PMID 33561251, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA editing activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables valine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables valine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables valine-tRNA ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in valyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in valyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in valyl-tRNA aminoacylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Valyl-tRNA synthetase, mitochondrial
    Names
    CG5660-PA
    CG5660-PB
    ValRS-m-PA
    ValRS-m-PB
    mitochondrial valyl-tRNA synthetase
    NP_001286988.1
    NP_648268.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8961274..8964769 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300059.1 → NP_001286988.1  Valyl-tRNA synthetase, mitochondrial, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286988.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VSR7
      Conserved Domains (4) summary
      cd07962
      Location:675 → 812
      Anticodon_Ia_Val; Anticodon-binding domain of valyl tRNA synthetases
      cd00817
      Location:73 → 675
      ValRS_core; catalytic core domain of valyl-tRNA synthetases
      PTZ00419
      Location:23 → 989
      PTZ00419; valyl-tRNA synthetase-like protein; Provisional
      pfam13603
      Location:268 → 391
      tRNA-synt_1_2; Leucyl-tRNA synthetase, Domain 2

    2. NM_140011.3 → NP_648268.1  Valyl-tRNA synthetase, mitochondrial, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648268.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VSR7
      Related
      FBpp0076287
      Conserved Domains (4) summary
      cd07962
      Location:675 → 812
      Anticodon_Ia_Val; Anticodon-binding domain of valyl tRNA synthetases
      cd00817
      Location:73 → 675
      ValRS_core; catalytic core domain of valyl-tRNA synthetases
      PTZ00419
      Location:23 → 989
      PTZ00419; valyl-tRNA synthetase-like protein; Provisional
      pfam13603
      Location:268 → 391
      tRNA-synt_1_2; Leucyl-tRNA synthetase, Domain 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VSR7 Q9VSR7

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