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    FucTA alpha1,3-fucosyltransferase A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39653, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FucTAprovided by FlyBase
    Official Full Name
    alpha1,3-fucosyltransferase Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036485
    Locus tag
    Dmel_CG6869
    See related
    AllianceGenome:FB:FBgn0036485
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    3-FucT; anon-EST:Posey285; CG6869; Dm alpha1; Dmel\CG6869; fucTA
    Summary
    Enables glycoprotein 3-alpha-L-fucosyltransferase activity. Involved in N-glycan fucosylation; nervous system development; and protein glycosylation. Located in Golgi medial cisterna. Is expressed in adult head; embryonic brain; embryonic/larval garland cell; larval nervous system; and larval ventral nerve cord. Used to study candidiasis. Orthologous to several human genes including FUT3 (fucosyltransferase 3 (Lewis blood group)); FUT4 (fucosyltransferase 4); and FUT5 (fucosyltransferase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See FucTA in Genome Data Viewer
    Location:
    71B5-71B6; 3-42 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15147137..15154395)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15140237..15147495)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45397 Neighboring gene uncharacterized protein Neighboring gene Peroxin 3 Neighboring gene Msh6 Neighboring gene Pre-mRNA processing factor 31 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of core alpha 1,3-fucosylated glycans and cloning of the requisite fucosyltransferase cDNA from Drosophila melanogaster. Potential basis of the neural anti-horseadish peroxidase epitope. Fabini G, et al. J Biol Chem, 2001 Jul 27. PMID 11382750
    2. Fucosyltransferase substrate specificity and the order of fucosylation in invertebrates. Paschinger K, et al. Glycobiology, 2005 May. PMID 15604090
    3. Modulation of neural carbohydrate epitope expression in Drosophila melanogaster cells. Rendic D, et al. J Biol Chem, 2006 Feb 10. PMID 16314421
    4. Reconstitution in vitro of the GDP-fucose biosynthetic pathways of Caenorhabditis elegans and Drosophila melanogaster. Rhomberg S, et al. FEBS J, 2006 May. PMID 16650000
    5. Neural-specific α3-fucosylation of N-linked glycans in the Drosophila embryo requires fucosyltransferase A and influences developmental signaling associated with O-glycosylation. Rendić D, et al. Glycobiology, 2010 Nov. PMID 20688784, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha-(1->3)-fucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-(1->3)-fucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-(1->3)-fucosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables fucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycoprotein 3-alpha-L-fucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-glycan fucosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fucosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi medial cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha1,3-fucosyltransferase A
    Names
    CG6869-PA
    CG6869-PB
    FucTA-PA
    FucTA-PB
    alpha1,3-fucosyltransferase
    core alpha1,3-fucosyltransferase
    core fucosyltransferase
    NP_001261872.1
    NP_648754.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15147137..15154395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140497.3 → NP_648754.2  alpha1,3-fucosyltransferase A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648754.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SYT5, Q9VUL9
      UniProtKB/TrEMBL
      I0DHK8
      Related
      FBpp0075394
      Conserved Domains (2) summary
      pfam00852
      Location:300 → 473
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:173 → 277
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    2. NM_001274943.1 → NP_001261872.1  alpha1,3-fucosyltransferase A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261872.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SYT5, Q9VUL9
      UniProtKB/TrEMBL
      I0DHK8
      Conserved Domains (2) summary
      pfam00852
      Location:300 → 473
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:173 → 277
      Glyco_tran_10_N; Fucosyltransferase, N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    I0DHK8 I0DHK8
    Q9VUL9.2 Q9VUL9

    Gene LinkOut

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    Chemical Information
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