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    gd gastrulation-defective [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32159, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gdprovided by FlyBase
    Official Full Name
    gastrulation-defectiveprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000808
    Locus tag
    Dmel_CG1505
    See related
    AllianceGenome:FB:FBgn0000808
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1505; Dmel\CG1505; fs(1)18; fs(1)190-5; fs(1)573; fs(1)A573; fs(1)gd; fs(1)M18; gas; Gd; GD; SP186
    Summary
    Enables serine-type endopeptidase activity. Involved in dorsal/ventral axis specification; protein maturation; and ventral furrow formation. Located in perivitelline space. Is expressed in follicle cell; nurse cell; oocyte; organism; and ovary. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    11A1-11A1; 1-38 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11985154..11987764, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11879567..11881797, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene PDZ domain containing 8 Neighboring gene cacophony Neighboring gene uncharacterized protein Neighboring gene twisted gastrulation

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Developmental analysis of fs(1)gastrulation defective, a dorsal-group gene of Drosophila melanogaster. Konrad KD, et al. Rouxs Arch Dev Biol, 1988 Mar. PMID 28305599
    2. A Drosophila calcium channel alpha1 subunit gene maps to a genetic locus associated with behavioral and visual defects. Smith LA, et al. J Neurosci, 1996 Dec 15. PMID 8987815, Free PMC Article
    3. Isolation of secreted proteins from Drosophila ovaries and embryos through in vivo BirA-mediated biotinylation. Stevens LM, et al. PLoS One, 2019. PMID 31658274, Free PMC Article
    4. Interallelic complementation at the Drosophila melanogaster gastrulation defective locus defines discrete functional domains of the protein. Ponomareff G, et al. Genetics, 2001 Oct. PMID 11606540, Free PMC Article
    5. Cactus-independent regulation of Dorsal nuclear import by the ventral signal. Drier EA, et al. Curr Biol, 2000 Jan 13. PMID 10660298

    See all (170) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. provision of three-dimensional model and role of cation binding sites in embryo patterning
      Title: Three-dimensional models of proteases involved in patterning of the Drosophila Embryo. Crucial role of predicted cation binding sites.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables serine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Toll receptor ligand protein activation cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in Toll receptor ligand protein activation cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in Toll receptor ligand protein activation cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal/ventral axis specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in dorsal/ventral axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ventral furrow formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in zymogen activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in perivitelline space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perivitelline space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gastrulation-defective
    Names
    CG1505-PC
    CG1505-PD
    CG1505-PE
    CG1505-PF
    gastrulation defective
    gd-PC
    gd-PD
    gd-PE
    gd-PF
    NP_001259478.1
    NP_001259479.1
    NP_001259480.1
    NP_001303552.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11985154..11987764 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316623.1 → NP_001303552.1  gastrulation-defective, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O62589
      Conserved Domains (3) summary
      smart00020
      Location:255 → 523
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:254 → 523
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam16030
      Location:27 → 121
      GD_N; Serine protease gd N-terminus

    2. NM_001272549.1 → NP_001259478.1  gastrulation-defective, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259478.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O62589
      Conserved Domains (3) summary
      smart00020
      Location:255 → 523
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:254 → 523
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam16030
      Location:27 → 121
      GD_N; Serine protease gd N-terminus

    3. NM_001272551.1 → NP_001259480.1  gastrulation-defective, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259480.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O62589
      Conserved Domains (1) summary
      pfam16030
      Location:27 → 121
      GD_N; Serine protease gd N-terminus

    4. NM_001272550.1 → NP_001259479.1  gastrulation-defective, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259479.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D9PTR2, M9PEE0, M9PGY7, M9PJK1, O62589, Q1EC38
      Conserved Domains (3) summary
      smart00020
      Location:258 → 526
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:257 → 526
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam16030
      Location:27 → 124
      GD_N; Serine protease gd N-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O62589.2 O62589

    Gene LinkOut

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