CG3527 uncharacterized protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CG3527provided by FlyBase
Official Full Name: uncharacterized proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0029714
Locus tag: Dmel_CG3527
See related: AllianceGenome:FB:FBgn0029714
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Dmel\CG3527; dNEP1
Summary: Predicted to enable rRNA (pseudouridine) methyltransferase activity and rRNA binding activity. Involved in defense response to bacterium. Predicted to be part of small-subunit processome. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Bowen-Conradi syndrome. Orthologous to human EMG1 (EMG1 N1-specific pseudouridine methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (4551973..4553006)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (4446006..4447039)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables rRNA (pseudouridine) methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables rRNA (pseudouridine) methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables rRNA (pseudouridine) methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables rRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rRNA base methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA base methylation	IEA Inferred from Electronic Annotation more info
involved_in rRNA methylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in ribosomal small subunit biogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info
part_of small-subunit processome	ISS Inferred from Sequence or Structural Similarity more info

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The following sections contain reference sequences that belong to a specific genome build. Explain