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    MED24 Mediator complex subunit 24 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38914, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MED24provided by FlyBase
    Official Full Name
    Mediator complex subunit 24provided by FlyBase
    Primary source
    FLYBASE:FBgn0035851
    Locus tag
    Dmel_CG7999
    See related
    AllianceGenome:FB:FBgn0035851
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7999; Dmel\CG7999; dTRAP100; l(3)psg5; med24; Med24; psg5; Trap100
    Summary
    Enables transcription coregulator activity. Involved in several processes, including autophagic cell death; instar larval or pupal development; and response to ecdysone. Part of mediator complex. Is expressed in embryonic/larval salivary gland and organism. Orthologous to human MED24 (mediator complex subunit 24). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MED24 in Genome Data Viewer
    Location:
    66B11-66B12; 3-22 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8191270..8196573)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8184370..8189673)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45870 Neighboring gene estrogen-related receptor Neighboring gene Autophagy-related 18a Neighboring gene uncharacterized protein Neighboring gene NEDD8-conjugating enzyme UbcE2M Neighboring gene Deoxyhypusine synthase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of a male-predominant antisense transcript underexpressed in hybrids of Drosophila pseudoobscura and D. persimilis. Noor MA, et al. Genetics, 2003 Dec. PMID 14704168, Free PMC Article
    2. A novel genetic system for analysis of co-activators for the N-terminal transactivation function domain of the human androgen receptor. Takeyama K, et al. Biosci Biotechnol Biochem, 2004 Jun. PMID 15215582
    3. Med24 and Mdh2 are required for Drosophila larval salivary gland cell death. Wang L, et al. Dev Dyn, 2010 Mar. PMID 20063412, Free PMC Article
    4. Digitor/dASCIZ Has Multiple Roles in Drosophila Development. Sengupta S, et al. PLoS One, 2016. PMID 27861562, Free PMC Article
    5. Rapid recombination mapping for high-throughput genetic screens in Drosophila. Sapiro AL, et al. G3 (Bethesda), 2013 Dec 9. PMID 24170736, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Med24 and Mdh2 are required for Drosophila larval salivary gland cell death
      Title: Med24 and Mdh2 are required for Drosophila larval salivary gland cell death.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transcription coregulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagic cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription initiation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pupal development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to ecdysone IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in salivary gland histolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mediator complex subunit 24
    Names
    CG7999-PA
    MED24-PA
    mediator

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8191270..8196573
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139928.5 → NP_648185.1  mediator complex subunit 24 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648185.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MQZ3, Q9GYW5, Q9VSF2
      Related
      FBpp0076417
      Conserved Domains (1) summary
      pfam11277
      Location:3 → 979
      Med24_N; Mediator complex subunit 24 N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VSF2.2 Q9VSF2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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