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    alpha-Catr alpha-catenin related [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 49713, updated on 9-Dec-2024

    Summary

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    Official Symbol
    alpha-Catrprovided by FlyBase
    Official Full Name
    alpha-catenin relatedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029105
    Locus tag
    Dmel_CG2987
    See related
    AllianceGenome:FB:FBgn0029105
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    alpha-catenin-related; alpha-catenin-Related; CG2987; Dmel\CG2987
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in Rho protein signal transduction. Is expressed in adult head; embryonic antennal sense organ; embryonic brain; and larval ventral nerve cord. Orthologous to human CTNNAL1 (catenin alpha like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See alpha-Catr in Genome Data Viewer
    Location:
    60A14-60A14; 2-105 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23957842..23961631)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19845365..19849154)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene thoc5 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Flavin-containing monooxygenase 1 Neighboring gene Aminolevulinate synthase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The THO complex is required for nucleolar integrity in Drosophila spermatocytes. Moon S, et al. Development, 2011 Sep. PMID 21828100
    2. Ribbon regulates morphogenesis of the Drosophila embryonic salivary gland through transcriptional activation and repression. Loganathan R, et al. Dev Biol, 2016 Jan 1. PMID 26477561, Free PMC Article
    3. Flying through the drosophila cytoskeletal genome. Goldstein LS, et al. J Cell Biol, 2000 Jul 24. PMID 10908588, Free PMC Article
    4. Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster. Ni JQ, et al. Nat Methods, 2008 Jan. PMID 18084299, Free PMC Article
    5. Next-generation large-scale binary protein interaction network for Drosophila melanogaster. Tang HW, et al. Nat Commun, 2023 Apr 15. PMID 37061542, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-catenin related
    Names
    CG2987-PA
    CG2987-PC
    alpha-Catr-PA
    alpha-Catr-PC
    alpha-catenin-related

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23957842..23961631
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143816.3 → NP_652073.2  alpha-catenin related, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652073.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TP52, Q9W1F1
      Related
      FBpp0072057
      Conserved Domains (1) summary
      pfam01044
      Location:52 → 755
      Vinculin; Vinculin family

    2. NM_166641.2 → NP_726389.4  alpha-catenin related, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726389.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0C4DHD7, C6TP52
      Conserved Domains (1) summary
      pfam01044
      Location:52 → 755
      Vinculin; Vinculin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0C4DHD7 A0A0C4DHD7
    Q9U523 Q9U523
    Q9W1F1 Q9W1F1

    Gene LinkOut

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