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    Pdzd8 PDZ domain containing 8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32157, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pdzd8provided by FlyBase
    Official Full Name
    PDZ domain containing 8provided by FlyBase
    Primary source
    FLYBASE:FBgn0030358
    Locus tag
    Dmel_CG10362
    See related
    AllianceGenome:FB:FBgn0030358
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10362; Dmel\CG10362; pdzd8
    Summary
    Predicted to enable lipid binding activity. Involved in mitochondrion-endoplasmic reticulum membrane tethering. Is active in mitochondria-associated endoplasmic reticulum membrane contact site. Is expressed in adult head. Used to study syndromic intellectual disability. Orthologous to human PDZD8 (PDZ domain containing 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pdzd8 in Genome Data Viewer
    Location:
    10F7-10F7; 1-37 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11926424..11930850, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11820457..11824883, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43157 Neighboring gene long non-coding RNA:CR32660 Neighboring gene sclp Neighboring gene cacophony Neighboring gene gastrulation-defective

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Decreasing pdzd8-mediated mito-ER contacts improves organismal fitness and mitigates Aβ(42) toxicity. Hewitt VL, et al. Life Sci Alliance, 2022 Nov. PMID 35831024, Free PMC Article
    2. PDZD8 Disruption Causes Cognitive Impairment in Humans, Mice, and Fruit Flies. Al-Amri AH, et al. Biol Psychiatry, 2022 Aug 15. PMID 35227461, Free PMC Article
    3. A fly GWAS for purine metabolites identifies human FAM214 homolog medusa, which acts in a conserved manner to enhance hyperuricemia-driven pathologies by modulating purine metabolism and the inflammatory response. Hilsabeck TAU, et al. Geroscience, 2022 Aug. PMID 35381951, Free PMC Article
    4. Insights from Drosophila on Aβ- and tau-induced mitochondrial dysfunction: mechanisms and tools. Varte V, et al. Front Neurosci, 2023. PMID 37139514, Free PMC Article
    5. Pleiotropic fitness effects of the Tre1-Gr5a region in Drosophila melanogaster. Rollmann SM, et al. Nat Genet, 2006 Jul. PMID 16783380

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrion-endoplasmic reticulum membrane tethering IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion-endoplasmic reticulum membrane tethering IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrion-endoplasmic reticulum membrane tethering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondria-associated endoplasmic reticulum membrane contact site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondria-associated endoplasmic reticulum membrane contact site IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondria-associated endoplasmic reticulum membrane contact site IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    PDZ domain containing 8
    Names
    CG10362-PA
    Pdzd8-PA
    NP_572771.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11926424..11930850 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132543.2 → NP_572771.1  PDZ domain containing 8 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572771.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYR9
      Related
      FBpp0073429
      Conserved Domains (3) summary
      COG0265
      Location:370 → 437
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00029
      Location:725 → 774
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl00117
      Location:358 → 424
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VYR9 Q9VYR9

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