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    CG31636 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318865, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG31636provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051636
    Locus tag
    Dmel_CG31636
    See related
    AllianceGenome:FB:FBgn0051636
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13770; Dmel\CG31636
    Summary
    Predicted to enable lipid transfer activity and phosphatidylinositol bisphosphate binding activity. Predicted to be involved in intermembrane lipid transfer. Predicted to be located in late endosome. Orthologous to human TTPAL (alpha tocopherol transfer protein like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG31636 in Genome Data Viewer
    Location:
    26F5-26F5; 2-21 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6656459..6658152, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6656459..6658152, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Transport and Golgi organization 1 Neighboring gene uncharacterized protein Neighboring gene Ubiquitination factor E4A Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Copy-number variation: the balance between gene dosage and expression in Drosophila melanogaster. Zhou J, et al. Genome Biol Evol, 2011. PMID 21979154, Free PMC Article
    2. Using FlyAtlas to identify better Drosophila melanogaster models of human disease. Chintapalli VR, et al. Nat Genet, 2007 Jun. PMID 17534367
    3. Control of protein degradation by E3 ubiquitin ligases in Drosophila eye development. Ou CY, et al. Trends Genet, 2003 Jul. PMID 12850443
    4. Microbiota-induced changes in drosophila melanogaster host gene expression and gut morphology. Broderick NA, et al. mBio, 2014 May 27. PMID 24865556, Free PMC Article
    5. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lipid transfer activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylinositol bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol bisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in intermembrane lipid transfer ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in late endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG31636-PA
    CG31636-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6656459..6658152 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298756.1 → NP_001285685.1  uncharacterized protein Dmel_CG31636, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285685.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C5WLR6, Q8IPJ5
      Conserved Domains (2) summary
      smart01100
      Location:27 → 72
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      cd00170
      Location:96 → 252
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

    2. NM_164699.2 → NP_723200.1  uncharacterized protein Dmel_CG31636, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723200.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C5WLR6, Q8IPJ5
      Related
      FBpp0078953
      Conserved Domains (2) summary
      smart01100
      Location:27 → 72
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      cd00170
      Location:96 → 252
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IPJ5 Q8IPJ5

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